AURKA
aurora kinase A
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 20382844 | RPMI8226, OPM1, primary plasma cells derived from bone marrow | Human | NO | |
| 22274399 | Primary glia derived from brain | Brain | Human | NO |
| 23180582 | Hs294T, SK-Mel-2, SK-Mel-5, SK-Mel-28 cells | Melanoma implants from patients | Human | NO |
| 24901229 | GIST882, GIST48, GIST43 | Gastrointestinal tract | Human | NO |
| 24989836 | DU-145, LNCaP, PC3 | Prostate | Human | NO |
| 25736378 | Mammary gland | Mouse | NO | |
| 27713168 | A549, A427, NCI-H1299 | Human | NO | |
| 27824120 | U937, HL-6, Jurkat, K562, NB4, KBM5, KBM5-T315I, 32D, Primary cells derived from bone marrow | Human, mouse | NO | |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 29548335 | Saos-2 | Human | YES | |
| 30987592 | MCF7 | Breast | Human | YES |
| 30988157 | IMR-90 | Human | YES | |
| 31578521 | hTERT-RPE1, Hep 3B, Huh-7 | Human | YES | |
| 31799499 | IMR-90, A549, SK-HEP-1, Huh-7, HLF | Human | NO | |
| 31920463 | IMR32, SK-N-BE, LAN-1, SK-N-SH, HepG2, U373 | Human, mouse | NO | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
| Â 23324396 | hTERT RPE-1 | Human | NO | |
| 32954665 | KYSE-450Â | Human | NO | |
GO terms:
Biological Process:
G2/M transition of mitotic cell cycle [GO:0000086],
mitotic cell cycle [GO:0000278],
protein phosphorylation [GO:0006468],
ubiquitin-dependent protein catabolic process [GO:0006511],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
spindle organization [GO:0007051],
mitotic spindle organization [GO:0007052],
spindle assembly involved in female meiosis I [GO:0007057],
mitotic centrosome separation [GO:0007100],
response to wounding [GO:0009611],
anterior/posterior axis specification [GO:0009948],
regulation of G2/M transition of mitotic cell cycle [GO:0010389],
negative regulation of gene expression [GO:0010629],
negative regulation of G2/M transition of mitotic cell cycle [GO:0010972],
peptidyl-serine phosphorylation [GO:0018105],
anaphase-promoting complex-dependent catabolic process [GO:0031145],
regulation of protein stability [GO:0031647],
negative regulation of protein binding [GO:0032091],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
regulation of cytokinesis [GO:0032465],
histone-serine phosphorylation [GO:0035404],
negative regulation of apoptotic process [GO:0043066],
positive regulation of mitotic nuclear division [GO:0045840],
regulation of centrosome cycle [GO:0046605],
protein autophosphorylation [GO:0046777],
cell division [GO:0051301],
centrosome localization [GO:0051642],
protein localization to centrosome [GO:0071539],
liver regeneration [GO:0097421],
positive regulation of oocyte maturation [GO:1900195],
regulation of signal transduction by p53 class mediator [GO:1901796],
neuron projection extension [GO:1990138],
meiotic spindle organization [GO:0000212],
microtubule cytoskeleton organization [GO:0000226],
cell cycle [GO:0007049],
centrosome cycle [GO:0007098],
phosphorylation [GO:0016310],
cell projection organization [GO:0030030],
meiotic cell cycle [GO:0051321],
negative regulation of spindle checkpoint [GO:0090233],
Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
histone serine kinase activity [GO:0035174],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
Cellular Component:
condensed nuclear chromosome, centromeric region [GO:0000780],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
centrosome [GO:0005813],
centriole [GO:0005814],
spindle [GO:0005819],
cytosol [GO:0005829],
spindle microtubule [GO:0005876],
cilium [GO:0005929],
microtubule cytoskeleton [GO:0015630],
midbody [GO:0030496],
spindle pole centrosome [GO:0031616],
chromosome passenger complex [GO:0032133],
germinal vesicle [GO:0042585],
axon hillock [GO:0043203],
pronucleus [GO:0045120],
perinuclear region of cytoplasm [GO:0048471],
spindle midzone [GO:0051233],
meiotic spindle [GO:0072687],
mitotic spindle pole [GO:0097431],
cytoplasm [GO:0005737],
microtubule organizing center [GO:0005815],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
cell projection [GO:0042995],
mitotic spindle [GO:0072686],