PPP1CA

protein phosphatase 1 catalytic subunit alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
18204081 Kidney, Colon Human NO
18800172 MEF Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
glycogen metabolic process [GO:0005977],
regulation of glycogen biosynthetic process [GO:0005979],
regulation of glycogen catabolic process [GO:0005981],
protein dephosphorylation [GO:0006470],
cell cycle [GO:0007049],
response to lead ion [GO:0010288],
viral process [GO:0016032],
dephosphorylation [GO:0016311],
lung development [GO:0030324],
negative regulation of protein binding [GO:0032091],
circadian regulation of gene expression [GO:0032922],
peptidyl-threonine dephosphorylation [GO:0035970],
regulation of translational initiation by eIF2 alpha dephosphorylation [GO:0036496],
regulation of circadian rhythm [GO:0042752],
entrainment of circadian clock by photoperiod [GO:0043153],
branching morphogenesis of an epithelial tube [GO:0048754],
cell division [GO:0051301],
regulation of canonical Wnt signaling pathway [GO:0060828],
peptidyl-serine dephosphorylation [GO:0070262],
cell-cell adhesion [GO:0098609],
beta-catenin destruction complex disassembly [GO:1904886],
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241],
carbohydrate metabolic process [GO:0005975],
regulation of translation [GO:0006417],
cellular process [GO:0009987],
rhythmic process [GO:0048511],

Molecular Function:
phosphoprotein phosphatase activity [GO:0004721],
protein serine/threonine phosphatase activity [GO:0004722],
protein binding [GO:0005515],
protein phosphatase 1 binding [GO:0008157],
phosphatase activity [GO:0016791],
ribonucleoprotein complex binding [GO:0043021],
metal ion binding [GO:0046872],
cadherin binding involved in cell-cell adhesion [GO:0098641],
hydrolase activity [GO:0016787],
macromolecular complex binding [GO:0044877],

Cellular Component:
protein phosphatase type 1 complex [GO:0000164],
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
glycogen granule [GO:0042587],
dendritic spine [GO:0043197],
perikaryon [GO:0043204],
extracellular exosome [GO:0070062],
PTW/PP1 phosphatase complex [GO:0072357],
presynapse [GO:0098793],
glutamatergic synapse [GO:0098978],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
postsynapse [GO:0098794],