ACAN

aggrecan

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30716534 Primary cells derived from nucleus pulposus Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
skeletal system development [GO:0001501],
cartilage condensation [GO:0001502],
chondrocyte development [GO:0002063],
proteolysis [GO:0006508],
cell adhesion [GO:0007155],
central nervous system development [GO:0007417],
heart development [GO:0007507],
keratan sulfate biosynthetic process [GO:0018146],
proteoglycan biosynthetic process [GO:0030166],
extracellular matrix organization [GO:0030198],
collagen fibril organization [GO:0030199],
keratan sulfate catabolic process [GO:0042340],
negative regulation of cell migration [GO:0030336],

Molecular Function:
extracellular matrix structural constituent [GO:0005201],
protein binding [GO:0005515],
hyaluronic acid binding [GO:0005540],
extracellular matrix structural constituent conferring compression resistance [GO:0030021],
carbohydrate binding [GO:0030246],
metal ion binding [GO:0046872],
calcium ion binding [GO:0005509],

Cellular Component:
extracellular region [GO:0005576],
basement membrane [GO:0005604],
Golgi lumen [GO:0005796],
extracellular matrix [GO:0031012],
lysosomal lumen [GO:0043202],
perisynaptic extracellular matrix [GO:0098966],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
extracellular space [GO:0005615],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
perineuronal net [GO:0072534],