PPARGC1A

PPARG coactivator 1 alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

GO terms:

Biological Process:
response to reactive oxygen species [GO:0000302],
mitophagy [GO:0000422],
temperature homeostasis [GO:0001659],
cellular glucose homeostasis [GO:0001678],
negative regulation of protein phosphorylation [GO:0001933],
response to dietary excess [GO:0002021],
response to ischemia [GO:0002931],
galactose metabolic process [GO:0006012],
gluconeogenesis [GO:0006094],
regulation of transcription, DNA-templated [GO:0006355],
transcription initiation from RNA polymerase II promoter [GO:0006367],
mRNA processing [GO:0006397],
mitochondrion organization [GO:0007005],
aging [GO:0007568],
digestion [GO:0007586],
circadian rhythm [GO:0007623],
androgen metabolic process [GO:0008209],
RNA splicing [GO:0008380],
response to cold [GO:0009409],
positive regulation of gene expression [GO:0010628],
positive regulation of mitochondrion organization [GO:0010822],
skeletal muscle atrophy [GO:0014732],
response to muscle activity [GO:0014850],
response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878],
negative regulation of smooth muscle cell migration [GO:0014912],
fatty acid oxidation [GO:0019395],
cerebellum development [GO:0021549],
respiratory electron transport chain [GO:0022904],
androgen receptor signaling pathway [GO:0030521],
forebrain development [GO:0030900],
circadian regulation of gene expression [GO:0032922],
cellular response to oxidative stress [GO:0034599],
positive regulation of histone acetylation [GO:0035066],
cellular response to potassium ion [GO:0035865],
response to starvation [GO:0042594],
regulation of circadian rhythm [GO:0042752],
response to leucine [GO:0043201],
negative regulation of neuron apoptotic process [GO:0043524],
cellular respiration [GO:0045333],
positive regulation of gluconeogenesis [GO:0045722],
negative regulation of glycolytic process [GO:0045820],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of fatty acid oxidation [GO:0046321],
positive regulation of smooth muscle cell proliferation [GO:0048661],
negative regulation of smooth muscle cell proliferation [GO:0048662],
protein stabilization [GO:0050821],
brown fat cell differentiation [GO:0050873],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
flavone metabolic process [GO:0051552],
adipose tissue development [GO:0060612],
macromolecular complex assembly [GO:0065003],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to nitrite [GO:0071250],
cellular response to caffeine [GO:0071313],
cellular response to fructose stimulus [GO:0071332],
cellular response to glucose stimulus [GO:0071333],
cellular response to interleukin-6 [GO:0071354],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to follicle-stimulating hormone stimulus [GO:0071372],
cellular response to estradiol stimulus [GO:0071392],
cellular response to hypoxia [GO:0071456],
cellular response to transforming growth factor beta stimulus [GO:0071560],
response to epinephrine [GO:0071871],
response to norepinephrine [GO:0071873],
negative regulation of mitochondrial fission [GO:0090258],
energy homeostasis [GO:0097009],
cellular response to thyroid hormone stimulus [GO:0097067],
negative regulation of neuron death [GO:1901215],
response to metformin [GO:1901558],
positive regulation of cellular respiration [GO:1901857],
positive regulation of mitochondrial DNA metabolic process [GO:1901860],
positive regulation of muscle tissue development [GO:1901863],
positive regulation of glomerular visceral epithelial cell apoptotic process [GO:1904635],
cellular response to ionomycin [GO:1904637],
cellular response to resveratrol [GO:1904639],
response to methionine [GO:1904640],
adaptive thermogenesis [GO:1990845],
positive regulation of progesterone biosynthetic process [GO:2000184],
negative regulation of receptor activity [GO:2000272],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
positive regulation of ATP biosynthetic process [GO:2001171],
response to activity [GO:0014823],
positive regulation of cellular metabolic process [GO:0031325],
rhythmic process [GO:0048511],

Molecular Function:
DNA binding [GO:0003677],
transcription cofactor activity [GO:0003712],
transcription coactivator activity [GO:0003713],
RNA binding [GO:0003723],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
ligand-dependent nuclear receptor binding [GO:0016922],
estrogen receptor binding [GO:0030331],
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374],
chromatin DNA binding [GO:0031490],
ubiquitin protein ligase binding [GO:0031625],
peroxisome proliferator activated receptor binding [GO:0042975],
alpha-tubulin binding [GO:0043014],
sequence-specific DNA binding [GO:0043565],
androgen receptor binding [GO:0050681],
promoter-specific chromatin binding [GO:1990841],
nucleic acid binding [GO:0003676],
chromatin binding [GO:0003682],
receptor binding [GO:0005102],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nuclear euchromatin [GO:0005719],
PML body [GO:0016605],
cytosolic ribosome [GO:0022626],
neuronal cell body [GO:0043025],
intracellular membrane-bounded organelle [GO:0043231],
apical dendrite [GO:0097440],
subsarcolemmal mitochondrion [GO:1990843],
interfibrillar mitochondrion [GO:1990844],
cytoplasm [GO:0005737],
cytosol [GO:0005829],