ATXN3

ataxin 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
microtubule cytoskeleton organization [GO:0000226],
nucleotide-excision repair [GO:0006289],
ubiquitin-dependent protein catabolic process [GO:0006511],
misfolded or incompletely synthesized protein catabolic process [GO:0006515],
chemical synaptic transmission [GO:0007268],
nervous system development [GO:0007399],
regulation of cell-substrate adhesion [GO:0010810],
protein deubiquitination [GO:0016579],
actin cytoskeleton organization [GO:0030036],
cellular response to heat [GO:0034605],
monoubiquitinated protein deubiquitination [GO:0035520],
exploration behavior [GO:0035640],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
intermediate filament cytoskeleton organization [GO:0045104],
protein K63-linked deubiquitination [GO:0070536],
histone H3 deacetylation [GO:0070932],
protein K48-linked deubiquitination [GO:0071108],
cellular response to misfolded protein [GO:0071218],
positive regulation of ERAD pathway [GO:1904294],
protein localization to cytosolic proteasome complex involved in ERAD pathway [GO:1904379],
proteolysis [GO:0006508],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
histone deacetylase activity [GO:0004407],
thiol-dependent ubiquitin-specific protease activity [GO:0004843],
protein binding [GO:0005515],
ubiquitin protein ligase binding [GO:0031625],
thiol-dependent ubiquitinyl hydrolase activity [GO:0036459],
ATPase binding [GO:0051117],
Lys63-specific deubiquitinase activity [GO:0061578],
Lys48-specific deubiquitinase activity [GO:1990380],
peptidase activity [GO:0008233],
cysteine-type peptidase activity [GO:0008234],
hydrolase activity [GO:0016787],
identical protein binding [GO:0042802],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrial matrix [GO:0005759],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
nuclear matrix [GO:0016363],
mitochondrial membrane [GO:0031966],
nuclear inclusion body [GO:0042405],
synapse [GO:0045202],