ATRX chromatin remodeler

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28855512 LS8817, LS8313,LS82, LS141, U2OS, A549, H1975 Human, mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31617338 HCT 116, MCF-7 Human NO
31155234 heart heart Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29254138 MEF Mouse NO
30987592 MCF7 Breast Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
meiotic spindle organization [GO:0000212],
DNA repair [GO:0006281],
DNA methylation [GO:0006306],
nucleosome assembly [GO:0006334],
DNA replication-independent nucleosome assembly [GO:0006336],
chromatin remodeling [GO:0006338],
regulation of transcription, DNA-templated [GO:0006355],
spermatogenesis [GO:0007283],
positive regulation of nuclear cell cycle DNA replication [GO:0010571],
DNA damage response, signal transduction by p53 class mediator [GO:0030330],
forebrain development [GO:0030900],
replication fork processing [GO:0031297],
positive regulation of telomere maintenance [GO:0032206],
DNA duplex unwinding [GO:0032508],
post-embryonic forelimb morphogenesis [GO:0035128],
multicellular organism growth [GO:0035264],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
Sertoli cell development [GO:0060009],
chromosome organization involved in meiotic cell cycle [GO:0070192],
protein localization to chromosome, telomeric region [GO:0070198],
seminiferous tubule development [GO:0072520],
cellular response to hydroxyurea [GO:0072711],
regulation of histone H3-K9 trimethylation [GO:1900112],
negative regulation of telomeric RNA transcription from RNA pol II promoter [GO:1901581],
positive regulation of telomeric RNA transcription from RNA pol II promoter [GO:1901582],
negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908],
chromatin organization [GO:0006325],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
DNA binding [GO:0003677],
DNA helicase activity [GO:0003678],
chromatin binding [GO:0003682],
protein binding [GO:0005515],
ATP binding [GO:0005524],
DNA translocase activity [GO:0015616],
methylated histone binding [GO:0035064],
histone binding [GO:0042393],
metal ion binding [GO:0046872],
chromo shadow domain binding [GO:0070087],
nucleotide binding [GO:0000166],
helicase activity [GO:0004386],
hydrolase activity [GO:0016787],

Cellular Component:
condensed nuclear chromosome, centromeric region [GO:0000780],
chromosome, telomeric region [GO:0000781],
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nuclear heterochromatin [GO:0005720],
pericentric heterochromatin [GO:0005721],
nuclear body [GO:0016604],
PML body [GO:0016605],
nuclear pericentric heterochromatin [GO:0031618],
nuclear subtelomeric heterochromatin [GO:1990707],
nuclear chromosome [GO:0000228],
heterochromatin [GO:0000792],
chromosome [GO:0005694],
cytoplasm [GO:0005737],