POLE2

DNA polymerase epsilon 2, accessory subunit

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
DNA replication [GO:0006260],
DNA-dependent DNA replication [GO:0006261],
DNA replication initiation [GO:0006270],
DNA repair [GO:0006281],
telomere maintenance via semi-conservative replication [GO:0032201],
error-prone translesion synthesis [GO:0042276],

Molecular Function:
DNA binding [GO:0003677],
DNA-directed DNA polymerase activity [GO:0003887],
protein binding [GO:0005515],

Cellular Component:
nucleoplasm [GO:0005654],
epsilon DNA polymerase complex [GO:0008622],
nuclear body [GO:0016604],
intracellular membrane-bounded organelle [GO:0043231],
nucleus [GO:0005634],