POLD1

DNA polymerase delta 1, catalytic subunit

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30895337 2BS, WI-38, primary mononuclear cells derived from blood Human NO
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
telomere maintenance [GO:0000723],
DNA synthesis involved in DNA repair [GO:0000731],
DNA replication [GO:0006260],
DNA-dependent DNA replication [GO:0006261],
DNA repair [GO:0006281],
transcription-coupled nucleotide-excision repair [GO:0006283],
base-excision repair, gap-filling [GO:0006287],
nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296],
nucleotide-excision repair, DNA gap filling [GO:0006297],
mismatch repair [GO:0006298],
response to UV [GO:0009411],
translesion synthesis [GO:0019985],
telomere maintenance via semi-conservative replication [GO:0032201],
nucleotide-excision repair, DNA incision [GO:0033683],
cellular response to UV [GO:0034644],
DNA damage response, detection of DNA damage [GO:0042769],
DNA replication proofreading [GO:0045004],
fatty acid homeostasis [GO:0055089],
error-free translesion synthesis [GO:0070987],
DNA biosynthetic process [GO:0071897],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
nucleotide binding [GO:0000166],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
damaged DNA binding [GO:0003684],
DNA-directed DNA polymerase activity [GO:0003887],
protein binding [GO:0005515],
3'-5'-exodeoxyribonuclease activity [GO:0008296],
metal ion binding [GO:0046872],
4 iron, 4 sulfur cluster binding [GO:0051539],
nucleic acid binding [GO:0003676],
nuclease activity [GO:0004518],
exonuclease activity [GO:0004527],
3'-5' exonuclease activity [GO:0008408],
transferase activity [GO:0016740],
nucleotidyltransferase activity [GO:0016779],
hydrolase activity [GO:0016787],
enzyme binding [GO:0019899],
iron-sulfur cluster binding [GO:0051536],

Cellular Component:
nucleotide-excision repair complex [GO:0000109],
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
membrane [GO:0016020],
aggresome [GO:0016235],
delta DNA polymerase complex [GO:0043625],