POLB

DNA polymerase beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29968395 AG6872, AG5397, MEF Human, mouse NO

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
DNA-dependent DNA replication [GO:0006261],
DNA repair [GO:0006281],
base-excision repair [GO:0006284],
base-excision repair, base-free sugar-phosphate removal [GO:0006286],
base-excision repair, gap-filling [GO:0006287],
base-excision repair, DNA ligation [GO:0006288],
pyrimidine dimer repair [GO:0006290],
nucleotide-excision repair, DNA gap filling [GO:0006297],
double-strand break repair via nonhomologous end joining [GO:0006303],
inflammatory response [GO:0006954],
cellular response to DNA damage stimulus [GO:0006974],
salivary gland morphogenesis [GO:0007435],
aging [GO:0007568],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
response to gamma radiation [GO:0010332],
somatic hypermutation of immunoglobulin genes [GO:0016446],
protein deubiquitination [GO:0016579],
response to ethanol [GO:0045471],
lymph node development [GO:0048535],
spleen development [GO:0048536],
homeostasis of number of cells [GO:0048872],
neuron apoptotic process [GO:0051402],
response to hyperoxia [GO:0055093],
immunoglobulin heavy chain V-D-J recombination [GO:0071707],
DNA biosynthetic process [GO:0071897],
DNA replication [GO:0006260],
apoptotic process [GO:0006915],
somatic diversification of immunoglobulins [GO:0016445],

Molecular Function:
damaged DNA binding [GO:0003684],
DNA-directed DNA polymerase activity [GO:0003887],
DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
lyase activity [GO:0016829],
enzyme binding [GO:0019899],
metal ion binding [GO:0046872],
DNA binding [GO:0003677],
transferase activity [GO:0016740],
nucleotidyltransferase activity [GO:0016779],
DNA polymerase activity [GO:0034061],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
microtubule [GO:0005874],
spindle microtubule [GO:0005876],
macromolecular complex [GO:0032991],
synaptonemal complex [GO:0000795],