PNP

purine nucleoside phosphorylase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
nucleobase-containing compound metabolic process [GO:0006139],
inosine catabolic process [GO:0006148],
purine nucleotide catabolic process [GO:0006195],
nicotinamide riboside catabolic process [GO:0006738],
immune response [GO:0006955],
nucleotide biosynthetic process [GO:0009165],
urate biosynthetic process [GO:0034418],
positive regulation of T cell proliferation [GO:0042102],
response to drug [GO:0042493],
purine-containing compound salvage [GO:0043101],
neutrophil degranulation [GO:0043312],
positive regulation of alpha-beta T cell differentiation [GO:0046638],
interleukin-2 secretion [GO:0070970],
positive regulation of T cell mediated cytotoxicity [GO:0001916],
deoxyinosine catabolic process [GO:0006149],
deoxyguanosine catabolic process [GO:0006161],
GTP biosynthetic process [GO:0006183],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
apoptotic mitochondrial changes [GO:0008637],
nucleoside metabolic process [GO:0009116],
response to gamma radiation [GO:0010332],
purine nucleoside metabolic process [GO:0042278],
positive regulation of B cell differentiation [GO:0045579],
positive regulation of DNA repair [GO:0045739],
dGTP metabolic process [GO:0046070],
guanosine catabolic process [GO:0046115],
negative regulation of T cell apoptotic process [GO:0070233],

Molecular Function:
nucleoside binding [GO:0001882],
purine nucleobase binding [GO:0002060],
purine-nucleoside phosphorylase activity [GO:0004731],
drug binding [GO:0008144],
phosphate ion binding [GO:0042301],
identical protein binding [GO:0042802],
catalytic activity [GO:0003824],
transferase activity [GO:0016740],
transferase activity, transferring glycosyl groups [GO:0016757],
transferase activity, transferring pentosyl groups [GO:0016763],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
secretory granule lumen [GO:0034774],
extracellular exosome [GO:0070062],
ficolin-1-rich granule lumen [GO:1904813],