ATR serine/threonine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16436511 Primary dermal fibroblasts derived from skin, WI26 VA4, WI38 VA13, primary epidermal keratinocytes, primary CD3+ cells Human NO
17136094 BJ, HMEC Human NO
21995812 Primary dermal fibroblasts derived from skin Foreskin Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30920150 Primary vascular progenitor cells derived from artery Human YES
31578521 BJ, Hep 3B Human YES

GO terms:

Biological Process:
DNA damage checkpoint [GO:0000077],
telomere maintenance [GO:0000723],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
multicellular organism development [GO:0007275],
negative regulation of DNA replication [GO:0008156],
peptidyl-serine phosphorylation [GO:0018105],
positive regulation of telomere maintenance via telomerase [GO:0032212],
cellular response to UV [GO:0034644],
interstrand cross-link repair [GO:0036297],
response to drug [GO:0042493],
positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517],
protein autophosphorylation [GO:0046777],
protein localization to chromosome, telomeric region [GO:0070198],
cellular response to gamma radiation [GO:0071480],
replicative senescence [GO:0090399],
establishment of RNA localization to telomere [GO:0097694],
establishment of macromolecular complex localization to telomere [GO:0097695],
regulation of cellular response to heat [GO:1900034],
regulation of signal transduction by p53 class mediator [GO:1901796],
positive regulation of telomerase catalytic core complex assembly [GO:1904884],
protein phosphorylation [GO:0006468],
embryo implantation [GO:0007566],
phosphorylation [GO:0016310],
regulation of protein binding [GO:0043393],
chromosome organization [GO:0051276],

Molecular Function:
DNA binding [GO:0003677],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
MutLalpha complex binding [GO:0032405],
MutSalpha complex binding [GO:0032407],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
chromosome [GO:0005694],
Golgi apparatus [GO:0005794],
PML body [GO:0016605],
XY body [GO:0001741],