PNKP

polynucleotide kinase 3'-phosphatase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
nucleotide-excision repair, DNA damage removal [GO:0000718],
DNA-dependent DNA replication [GO:0006261],
DNA repair [GO:0006281],
response to oxidative stress [GO:0006979],
response to radiation [GO:0009314],
negative regulation of protein ADP-ribosylation [GO:0010836],
dephosphorylation [GO:0016311],
positive regulation of telomere maintenance via telomerase [GO:0032212],
DNA damage response, detection of DNA damage [GO:0042769],
nucleotide phosphorylation [GO:0046939],
nucleoside monophosphate phosphorylation [GO:0046940],
positive regulation of telomerase activity [GO:0051973],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
polynucleotide 3' dephosphorylation [GO:0098506],
positive regulation of telomere capping [GO:1904355],
positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034],
cellular response to DNA damage stimulus [GO:0006974],
metabolic process [GO:0008152],
phosphorylation [GO:0016310],

Molecular Function:
damaged DNA binding [GO:0003684],
double-stranded DNA binding [GO:0003690],
endonuclease activity [GO:0004519],
protein binding [GO:0005515],
ATP binding [GO:0005524],
purine nucleotide binding [GO:0017076],
polynucleotide 3'-phosphatase activity [GO:0046403],
ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404],
nucleoside phosphate kinase activity [GO:0050145],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
mitochondrion [GO:0005739],
membrane [GO:0016020],