PMPCA

peptidase, mitochondrial processing subunit alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 IPSC-MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
protein processing involved in protein targeting to mitochondrion [GO:0006627],
mitochondrial calcium ion transport [GO:0006851],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
metal ion binding [GO:0046872],
catalytic activity [GO:0003824],
metallopeptidase activity [GO:0008237],

Cellular Component:
extracellular space [GO:0005615],
mitochondrion [GO:0005739],
mitochondrial inner membrane [GO:0005743],
mitochondrial processing peptidase complex [GO:0017087],
membrane [GO:0016020],