PML

PML nuclear body scaffold

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
12093737 WI-38 Human NO
14712214 IMR-90 Human NO
18056407 Primary fibroblasts derived from skin Human NO
20699642 HeLa, U2OS, HCT116, BJ human NO
21205865 U2OS, IMR-90 Human NO
22002537 WI-38, MEF, NIH3T3, U2OS, MCF7 Human NO
22359342 IMR-90, MEF Lung Human, mouse NO
23555779 VHM Skin Human NO
24351540 MEF Mouse NO
25354534 MSC Bone marrow Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31635050 MCF-7 Human NO
31636448 Primary neuron derived from brain, HT-22 Mouse NO
31945125 Primary astrocytes derived from brain Human YES
32276991 MEF Mouse No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
26119943 293T, HeLa, A549, U2OS, WI-38, MRC-5, SK-LU-1 Human NO
28486108 NB4, HEK 293T, CHO Kidney, Bone marrow, Ovary Human, mouse NO

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
regulation of protein phosphorylation [GO:0001932],
regulation of transcription, DNA-templated [GO:0006355],
protein import into nucleus [GO:0006606],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
cell cycle arrest [GO:0007050],
transforming growth factor beta receptor signaling pathway [GO:0007179],
common-partner SMAD protein phosphorylation [GO:0007182],
negative regulation of cell proliferation [GO:0008285],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631],
response to UV [GO:0009411],
response to gamma radiation [GO:0010332],
regulation of calcium ion transport into cytosol [GO:0010522],
fibroblast migration [GO:0010761],
viral process [GO:0016032],
negative regulation of angiogenesis [GO:0016525],
protein ubiquitination [GO:0016567],
myeloid cell differentiation [GO:0030099],
regulation of cell adhesion [GO:0030155],
negative regulation of cell growth [GO:0030308],
PML body organization [GO:0030578],
positive regulation of telomere maintenance [GO:0032206],
endoplasmic reticulum calcium ion homeostasis [GO:0032469],
circadian regulation of gene expression [GO:0032922],
response to cytokine [GO:0034097],
regulation of circadian rhythm [GO:0042752],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
entrainment of circadian clock by photoperiod [GO:0043153],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
innate immune response [GO:0045087],
cell fate commitment [GO:0045165],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of fibroblast proliferation [GO:0048146],
retinoic acid receptor signaling pathway [GO:0048384],
negative regulation of interleukin-1 beta secretion [GO:0050713],
maintenance of protein location in nucleus [GO:0051457],
defense response to virus [GO:0051607],
interferon-gamma-mediated signaling pathway [GO:0060333],
branching involved in mammary gland duct morphogenesis [GO:0060444],
macromolecular complex assembly [GO:0065003],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
cellular response to interleukin-4 [GO:0071353],
cellular senescence [GO:0090398],
extrinsic apoptotic signaling pathway [GO:0097191],
regulation of signal transduction by p53 class mediator [GO:1901796],
negative regulation of viral release from host cell [GO:1902187],
cellular response to leukemia inhibitory factor [GO:1990830],
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059],
regulation of double-strand break repair [GO:2000779],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
positive regulation of defense response to virus by host [GO:0002230],
immune system process [GO:0002376],
protein targeting [GO:0006605],
apoptotic process [GO:0006915],
cell aging [GO:0007569],
positive regulation of histone deacetylation [GO:0031065],
negative regulation of telomere maintenance via telomerase [GO:0032211],
negative regulation of translation in response to oxidative stress [GO:0032938],
regulation of MHC class I biosynthetic process [GO:0045343],
positive regulation of MHC class I biosynthetic process [GO:0045345],
negative regulation of mitotic cell cycle [GO:0045930],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
rhythmic process [GO:0048511],
negative regulation of interleukin-1 secretion [GO:0050711],
protein stabilization [GO:0050821],
negative regulation of telomerase activity [GO:0051974],
positive regulation of apoptotic process involved in mammary gland involution [GO:0060058],
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332],
positive regulation of protein localization to chromosome, telomeric region [GO:1904816],
positive regulation of apoptotic signaling pathway [GO:2001235],

Molecular Function:
DNA binding [GO:0003677],
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
ubiquitin protein ligase binding [GO:0031625],
SUMO binding [GO:0032183],
protein homodimerization activity [GO:0042803],
SMAD binding [GO:0046332],
transcription coactivator activity [GO:0003713],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
cobalt ion binding [GO:0050897],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
chromatin [GO:0000785],
heterochromatin [GO:0000792],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
nuclear matrix [GO:0016363],
PML body [GO:0016605],
early endosome membrane [GO:0031901],
extrinsic component of endoplasmic reticulum membrane [GO:0042406],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
membrane [GO:0016020],
nuclear membrane [GO:0031965],