ATP7B

ATPase copper transporting beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES

GO terms:

Biological Process:
copper ion transport [GO:0006825],
cellular copper ion homeostasis [GO:0006878],
cellular zinc ion homeostasis [GO:0006882],
lactation [GO:0007595],
copper ion import [GO:0015677],
intracellular copper ion transport [GO:0015680],
ion transmembrane transport [GO:0034220],
response to copper ion [GO:0046688],
sequestering of calcium ion [GO:0051208],
copper ion export [GO:0060003],
divalent inorganic cation transport [GO:0072511],
ion transport [GO:0006811],
cation transport [GO:0006812],
metal ion transport [GO:0030001],
cellular response to copper ion [GO:0071280],
cellular response to manganese ion [GO:0071287],

Molecular Function:
copper ion transmembrane transporter activity [GO:0005375],
copper ion binding [GO:0005507],
protein binding [GO:0005515],
ATP binding [GO:0005524],
copper-transporting ATPase activity [GO:0043682],
nucleotide binding [GO:0000166],
zinc ion binding [GO:0008270],
cation-transporting ATPase activity [GO:0019829],
metal ion binding [GO:0046872],

Cellular Component:
Golgi membrane [GO:0000139],
mitochondrion [GO:0005739],
late endosome [GO:0005770],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
cytoplasmic vesicle [GO:0031410],
trans-Golgi network membrane [GO:0032588],
perinuclear region of cytoplasm [GO:0048471],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
plasma membrane [GO:0005886],
bicellular tight junction [GO:0005923],
integral component of membrane [GO:0016021],
apical part of cell [GO:0045177],
occluding junction [GO:0070160],