PLSCR1

phospholipid scramblase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31183403 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31915373 Hheart_LA_VS healthy Cardiomyocyte,Endothelial cell Human NO

GO terms:

Biological Process:
phosphatidylserine biosynthetic process [GO:0006659],
apoptotic process [GO:0006915],
acute-phase response [GO:0006953],
positive regulation of gene expression [GO:0010628],
phospholipid scrambling [GO:0017121],
platelet activation [GO:0030168],
regulation of mast cell activation [GO:0033003],
response to interferon-beta [GO:0035456],
negative regulation of viral genome replication [GO:0045071],
positive regulation of innate immune response [GO:0045089],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
defense response to virus [GO:0051607],
regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368],
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373],
immune response [GO:0006955],
myeloid cell differentiation [GO:0030099],
negative regulation of protein binding [GO:0032091],
response to interferon-alpha [GO:0035455],
positive regulation of apoptotic process [GO:0043065],
phosphatidylserine exposure on apoptotic cell surface [GO:0070782],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to cytokine stimulus [GO:0071345],
intrinsic apoptotic signaling pathway [GO:0097193],
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231],

Molecular Function:
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
epidermal growth factor receptor binding [GO:0005154],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
SH3 domain binding [GO:0017124],
phospholipid scramblase activity [GO:0017128],
enzyme binding [GO:0019899],
CD4 receptor binding [GO:0042609],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
integral component of membrane [GO:0016021],