PLOD3

procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
endothelial cell morphogenesis [GO:0001886],
protein O-linked glycosylation [GO:0006493],
protein localization [GO:0008104],
peptidyl-lysine hydroxylation [GO:0017185],
neural tube development [GO:0021915],
collagen fibril organization [GO:0030199],
cellular response to hormone stimulus [GO:0032870],
collagen metabolic process [GO:0032963],
vasodilation [GO:0042311],
hydroxylysine biosynthetic process [GO:0046947],
epidermis morphogenesis [GO:0048730],
oxidation-reduction process [GO:0055114],
lung morphogenesis [GO:0060425],
basement membrane assembly [GO:0070831],
metabolic process [GO:0008152],

Molecular Function:
iron ion binding [GO:0005506],
protein binding [GO:0005515],
procollagen-lysine 5-dioxygenase activity [GO:0008475],
L-ascorbic acid binding [GO:0031418],
procollagen glucosyltransferase activity [GO:0033823],
procollagen galactosyltransferase activity [GO:0050211],
catalytic activity [GO:0003824],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705],
transferase activity [GO:0016740],
transferase activity, transferring glycosyl groups [GO:0016757],
metal ion binding [GO:0046872],
dioxygenase activity [GO:0051213],

Cellular Component:
extracellular space [GO:0005615],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum lumen [GO:0005788],
endoplasmic reticulum membrane [GO:0005789],
rough endoplasmic reticulum [GO:0005791],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
extracellular exosome [GO:0070062],
extracellular region [GO:0005576],
membrane [GO:0016020],