PLEKHM1

pleckstrin homology and RUN domain containing M1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
autophagy [GO:0006914],
protein transport [GO:0015031],
lysosome localization [GO:0032418],
intracellular signal transduction [GO:0035556],
positive regulation of bone resorption [GO:0045780],
positive regulation of ruffle assembly [GO:1900029],

Molecular Function:
metal ion binding [GO:0046872],
protein binding [GO:0005515],

Cellular Component:
nucleolus [GO:0005730],
lysosomal membrane [GO:0005765],
endosome membrane [GO:0010008],
intracellular membrane-bounded organelle [GO:0043231],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
endosome [GO:0005768],
membrane [GO:0016020],