PLD2

phospholipase D2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31155496 Primary β cells derived from pancreas Mouse YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25064843 IMR-90, HCT116 Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
phosphatidic acid biosynthetic process [GO:0006654],
cytoskeleton organization [GO:0007010],
small GTPase mediated signal transduction [GO:0007264],
synaptic vesicle recycling [GO:0036465],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
inositol lipid-mediated signaling [GO:0048017],
cell motility [GO:0048870],
response to hypoxia [GO:0001666],
G-protein coupled receptor internalization [GO:0002031],
lipid metabolic process [GO:0006629],
receptor-mediated endocytosis [GO:0006898],
phospholipid catabolic process [GO:0009395],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
response to organic cyclic compound [GO:0014070],
lipid catabolic process [GO:0016042],
positive regulation of cell migration [GO:0030335],
neuron projection development [GO:0031175],
response to hydrogen peroxide [GO:0042542],
positive regulation of mast cell degranulation [GO:0043306],
response to peptide hormone [GO:0043434],
positive regulation of cell adhesion [GO:0045785],
positive regulation of receptor-mediated endocytosis [GO:0048260],

Molecular Function:
protein binding [GO:0005515],
phosphatidylinositol binding [GO:0035091],
N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290],
catalytic activity [GO:0003824],
phospholipase D activity [GO:0004630],
protein kinase C binding [GO:0005080],
hydrolase activity [GO:0016787],

Cellular Component:
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
presynapse [GO:0098793],
nucleus [GO:0005634],
Golgi apparatus [GO:0005794],
caveola [GO:0005901],
membrane [GO:0016020],
lamellipodium [GO:0030027],
brush border membrane [GO:0031526],
sarcolemma [GO:0042383],