PLCB1

phospholipase C beta 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
G2/M transition of mitotic cell cycle [GO:0000086],
oocyte maturation [GO:0001556],
mRNA processing [GO:0006397],
lipid metabolic process [GO:0006629],
cell adhesion [GO:0007155],
signal transduction [GO:0007165],
G-protein coupled acetylcholine receptor signaling pathway [GO:0007213],
glutamate receptor signaling pathway [GO:0007215],
brain development [GO:0007420],
memory [GO:0007613],
regulation of G-protein coupled receptor protein signaling pathway [GO:0008277],
insulin receptor signaling pathway [GO:0008286],
lipid catabolic process [GO:0016042],
cerebral cortex development [GO:0021987],
erythrocyte differentiation [GO:0030218],
macrophage differentiation [GO:0030225],
phosphatidylinositol catabolic process [GO:0031161],
positive regulation of sodium:proton antiporter activity [GO:0032417],
positive regulation of interleukin-12 production [GO:0032735],
inositol trisphosphate metabolic process [GO:0032957],
response to monosaccharide [GO:0034284],
intracellular signal transduction [GO:0035556],
interleukin-12-mediated signaling pathway [GO:0035722],
interleukin-15-mediated signaling pathway [GO:0035723],
positive regulation of embryonic development [GO:0040019],
response to peptide hormone [GO:0043434],
fat cell differentiation [GO:0045444],
positive regulation of myoblast differentiation [GO:0045663],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of JNK cascade [GO:0046330],
insulin-like growth factor receptor signaling pathway [GO:0048009],
phosphatidylinositol-mediated signaling [GO:0048015],
positive regulation of developmental growth [GO:0048639],
regulation of cell cycle [GO:0051726],
activation of meiosis involved in egg activation [GO:0060466],
interleukin-1-mediated signaling pathway [GO:0070498],
regulation of fertilization [GO:0080154],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
cellular response to fluoride [GO:1902618],
cellular response to vasopressin [GO:1904117],
cellular response to ionomycin [GO:1904637],
positive regulation of acrosome reaction [GO:2000344],
negative regulation of monocyte extravasation [GO:2000438],
positive regulation of CD24 biosynthetic process [GO:2000560],
G-protein coupled receptor signaling pathway [GO:0007186],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
positive regulation of GTPase activity [GO:0043547],
inositol phosphate metabolic process [GO:0043647],
phosphatidylinositol metabolic process [GO:0046488],

Molecular Function:
phosphatidylinositol phospholipase C activity [GO:0004435],
GTPase activator activity [GO:0005096],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
lamin binding [GO:0005521],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
phosphoric diester hydrolase activity [GO:0008081],
hydrolase activity [GO:0016787],
enzyme binding [GO:0019899],
identical protein binding [GO:0042802],
phospholipase C activity [GO:0004629],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
nuclear speck [GO:0016607],
macromolecular complex [GO:0032991],
myelin sheath [GO:0043209],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
nuclear membrane [GO:0031965],
extracellular exosome [GO:0070062],
postsynapse [GO:0098794],