phospholipase A2 group IVC

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
phospholipid metabolic process [GO:0006644],
inflammatory response [GO:0006954],
parturition [GO:0007567],
arachidonic acid metabolic process [GO:0019369],
intracellular signal transduction [GO:0035556],
phosphatidylinositol acyl-chain remodeling [GO:0036149],
phosphatidylcholine acyl-chain remodeling [GO:0036151],
phosphatidylethanolamine acyl-chain remodeling [GO:0036152],
glycerophospholipid catabolic process [GO:0046475],
lipid metabolic process [GO:0006629],
phospholipid catabolic process [GO:0009395],
lipid catabolic process [GO:0016042],

Molecular Function:
lysophospholipase activity [GO:0004622],
phospholipase A2 activity [GO:0004623],
calcium ion binding [GO:0005509],
phospholipid binding [GO:0005543],
calcium-dependent phospholipid binding [GO:0005544],
phosphatidylcholine 1-acylhydrolase activity [GO:0008970],
calcium-dependent phospholipase A2 activity [GO:0047498],
calcium-independent phospholipase A2 activity [GO:0047499],
phospholipase activity [GO:0004620],
hydrolase activity [GO:0016787],

Cellular Component:
nuclear envelope [GO:0005635],
nucleoplasm [GO:0005654],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
cell cortex [GO:0005938],
membrane [GO:0016020],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],