praja ring finger ubiquitin ligase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31636448 HT-22 Mouse NO

GO terms:

Biological Process:
inflammatory response [GO:0006954],
long-term memory [GO:0007616],
regulation of protein kinase A signaling [GO:0010738],
protein ubiquitination [GO:0016567],
positive regulation of toll-like receptor 2 signaling pathway [GO:0034137],
hippo signaling [GO:0035329],
regulation of macrophage activation [GO:0043030],
innate immune response [GO:0045087],
positive regulation of JNK cascade [GO:0046330],
positive regulation of p38MAPK cascade [GO:1900745],

Molecular Function:
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
protein kinase A catalytic subunit binding [GO:0034236],
protein kinase A regulatory subunit binding [GO:0034237],
metal ion binding [GO:0046872],
transferase activity [GO:0016740],

Cellular Component:
Golgi membrane [GO:0000139],
cytoplasm [GO:0005737],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
postsynaptic density [GO:0014069],
intermediate filament cytoskeleton [GO:0045111],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
membrane [GO:0016020],
cell junction [GO:0030054],
synapse [GO:0045202],