PINK1

PTEN induced kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA376 Skin, Lung Human YES
30892080 Primary epithelial cells derived from lung Mouse NO
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25714760 HBEC Human NO
29890141 Primary nucleus pulposus cells derived from intervertebral disc Intervertebral Disc Human NO
31593750 Primary cells derived from bronchus Human NO
31983656 MSC Human YES
33299530 kidney Mouse No

GO terms:

Biological Process:
mitophagy [GO:0000422],
positive regulation of protein phosphorylation [GO:0001934],
regulation of oxidative phosphorylation [GO:0002082],
response to ischemia [GO:0002931],
protein phosphorylation [GO:0006468],
ubiquitin-dependent protein catabolic process [GO:0006511],
response to oxidative stress [GO:0006979],
mitochondrion organization [GO:0007005],
regulation of hydrogen peroxide metabolic process [GO:0010310],
negative regulation of gene expression [GO:0010629],
regulation of mitochondrion organization [GO:0010821],
positive regulation of peptidase activity [GO:0010952],
macroautophagy [GO:0016236],
positive regulation of macroautophagy [GO:0016239],
negative regulation of macroautophagy [GO:0016242],
protein ubiquitination [GO:0016567],
peptidyl-serine phosphorylation [GO:0018105],
respiratory electron transport chain [GO:0022904],
regulation of protein ubiquitination [GO:0031396],
positive regulation of protein ubiquitination [GO:0031398],
activation of protein kinase B activity [GO:0032148],
positive regulation of synaptic transmission, dopaminergic [GO:0032226],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
positive regulation of dopamine secretion [GO:0033603],
cellular response to oxidative stress [GO:0034599],
positive regulation of protein dephosphorylation [GO:0035307],
intracellular signal transduction [GO:0035556],
peptidyl-serine autophosphorylation [GO:0036289],
TORC2 signaling [GO:0038203],
regulation of apoptotic process [GO:0042981],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
regulation of protein complex assembly [GO:0043254],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of translation [GO:0045727],
negative regulation of JNK cascade [GO:0046329],
protein stabilization [GO:0050821],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of ubiquitin-protein transferase activity [GO:0051443],
regulation of mitochondrial membrane potential [GO:0051881],
positive regulation of protein kinase B signaling [GO:0051897],
regulation of proteasomal protein catabolic process [GO:0061136],
cellular response to hypoxia [GO:0071456],
establishment of protein localization to mitochondrion [GO:0072655],
maintenance of protein location in mitochondrion [GO:0072656],
positive regulation of mitochondrial fission [GO:0090141],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
negative regulation of mitochondrial fission [GO:0090258],
cellular response to toxic substance [GO:0097237],
mitophagy in response to mitochondrial depolarization [GO:0098779],
mitochondrion to lysosome transport [GO:0099074],
regulation of cellular response to oxidative stress [GO:1900407],
positive regulation of histone deacetylase activity [GO:1901727],
regulation of synaptic vesicle transport [GO:1902803],
negative regulation of autophagosome assembly [GO:1902902],
positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958],
regulation of mitophagy [GO:1903146],
negative regulation of mitophagy [GO:1903147],
negative regulation of oxidative stress-induced cell death [GO:1903202],
negative regulation of oxidative stress-induced neuron death [GO:1903204],
regulation of protein targeting to mitochondrion [GO:1903214],
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298],
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384],
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751],
positive regulation of cristae formation [GO:1903852],
positive regulation of protein targeting to mitochondrion [GO:1903955],
positive regulation of free ubiquitin chain polymerization [GO:1904544],
positive regulation of NMDA glutamate receptor activity [GO:1904783],
cellular response to hydrogen sulfide [GO:1904881],
regulation of reactive oxygen species metabolic process [GO:2000377],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
positive regulation of ATP biosynthetic process [GO:2001171],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],
autophagy [GO:0006914],
phosphorylation [GO:0016310],
positive regulation of catecholamine secretion [GO:0033605],
negative regulation of apoptotic process [GO:0043066],
regulation of neuron apoptotic process [GO:0043523],
negative regulation of neuron death [GO:1901215],
positive regulation of mitophagy in response to mitochondrial depolarization [GO:1904925],

Molecular Function:
magnesium ion binding [GO:0000287],
protease binding [GO:0002020],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
calcium-dependent protein kinase activity [GO:0010857],
kinase activity [GO:0016301],
peptidase activator activity [GO:0016504],
ubiquitin protein ligase binding [GO:0031625],
protein kinase B binding [GO:0043422],
macromolecular complex binding [GO:0044877],
C3HC4-type RING finger domain binding [GO:0055131],
TORC2 complex binding [GO:1904841],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
chromatin [GO:0000785],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
mitochondrial inner membrane [GO:0005743],
mitochondrial intermembrane space [GO:0005758],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
axon [GO:0030424],
growth cone [GO:0030426],
integral component of mitochondrial outer membrane [GO:0031307],
cell body [GO:0044297],
perinuclear region of cytoplasm [GO:0048471],
Lewy body [GO:0097413],
astrocyte projection [GO:0097449],
integral component of membrane [GO:0016021],