PIK3C3

phosphatidylinositol 3-kinase catalytic subunit type 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31931659 WI-38 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
protein phosphorylation [GO:0006468],
protein lipidation [GO:0006497],
phosphatidylinositol biosynthetic process [GO:0006661],
endocytosis [GO:0006897],
autophagy [GO:0006914],
endosome organization [GO:0007032],
cell cycle [GO:0007049],
macroautophagy [GO:0016236],
protein processing [GO:0016485],
pexophagy [GO:0030242],
regulation of cytokinesis [GO:0032465],
toll-like receptor 9 signaling pathway [GO:0034162],
protein localization to pre-autophagosomal structure [GO:0034497],
phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092],
cellular response to glucose starvation [GO:0042149],
response to leucine [GO:0043201],
early endosome to late endosome transport [GO:0045022],
phosphatidylinositol phosphorylation [GO:0046854],
phosphatidylinositol-mediated signaling [GO:0048015],
regulation of protein secretion [GO:0050708],
cell division [GO:0051301],
cellular response to starvation [GO:0009267],
phosphorylation [GO:0016310],

Molecular Function:
protein kinase activity [GO:0004672],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
1-phosphatidylinositol-3-kinase activity [GO:0016303],
phosphatidylinositol kinase activity [GO:0052742],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
phosphatidylinositol 3-kinase activity [GO:0035004],

Cellular Component:
pre-autophagosomal structure [GO:0000407],
cytoplasm [GO:0005737],
endosome [GO:0005768],
late endosome [GO:0005770],
peroxisome [GO:0005777],
cytosol [GO:0005829],
axoneme [GO:0005930],
membrane [GO:0016020],
midbody [GO:0030496],
phagocytic vesicle membrane [GO:0030670],
phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271],
phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272],
phosphatidylinositol 3-kinase complex, class III [GO:0035032],
autolysosome [GO:0044754],
cytoplasmic vesicle [GO:0031410],
phagocytic vesicle [GO:0045335],