PIK3C2A

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
 23324396 hTERT RPE-1 Human NO

GO terms:

Biological Process:
phosphatidylinositol biosynthetic process [GO:0006661],
exocytosis [GO:0006887],
endocytosis [GO:0006897],
epidermal growth factor receptor signaling pathway [GO:0007173],
insulin receptor signaling pathway [GO:0008286],
positive regulation of autophagy [GO:0010508],
phosphatidylinositol 3-kinase signaling [GO:0014065],
vascular smooth muscle contraction [GO:0014829],
cell migration [GO:0016477],
phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092],
phosphatidylinositol phosphorylation [GO:0046854],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
phosphatidylinositol-mediated signaling [GO:0048015],
clathrin coat assembly [GO:0048268],
membrane organization [GO:0061024],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
cellular response to starvation [GO:0009267],
macroautophagy [GO:0016236],
phosphorylation [GO:0016310],
negative regulation of zinc ion transmembrane transport [GO:0071583],
autophagosome organization [GO:1905037],

Molecular Function:
ATP binding [GO:0005524],
1-phosphatidylinositol-3-kinase activity [GO:0016303],
phosphatidylinositol 3-kinase activity [GO:0035004],
1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005],
phosphatidylinositol binding [GO:0035091],
phosphatidylinositol kinase activity [GO:0052742],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
phosphatidylinositol 3-kinase complex [GO:0005942],
membrane [GO:0016020],
clathrin-coated vesicle [GO:0030136],
vesicle [GO:0031982],
extracellular exosome [GO:0070062],
nucleus [GO:0005634],
cytoplasmic vesicle [GO:0031410],