PIF1
PIF1 5'-to-3' DNA helicase
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 27323328 | Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni | Human | YES | |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 29548335 | Saos-2 | Human | YES | |
| 30987592 | MCF7 | Breast | Human | YES |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
mitochondrial genome maintenance [GO:0000002],
telomere maintenance [GO:0000723],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
DNA recombination [GO:0006310],
regulation of telomere maintenance [GO:0032204],
negative regulation of telomere maintenance via telomerase [GO:0032211],
DNA duplex unwinding [GO:0032508],
negative regulation of telomerase activity [GO:0051974],
cellular response to DNA damage stimulus [GO:0006974],
Molecular Function:
magnesium ion binding [GO:0000287],
ATP binding [GO:0005524],
telomerase inhibitor activity [GO:0010521],
single-stranded DNA-dependent ATP-dependent DNA helicase activity [GO:0017116],
5'-3' DNA/RNA helicase activity [GO:0033678],
telomeric DNA binding [GO:0042162],
5'-3' DNA helicase activity [GO:0043139],
G-quadruplex DNA binding [GO:0051880],
nucleotide binding [GO:0000166],
DNA binding [GO:0003677],
DNA helicase activity [GO:0003678],
helicase activity [GO:0004386],
protein binding [GO:0005515],
hydrolase activity [GO:0016787],
Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
replication fork [GO:0005657],
mitochondrion [GO:0005739],
nucleus [GO:0005634],