PIF1 5'-to-3' DNA helicase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
mitochondrial genome maintenance [GO:0000002],
telomere maintenance [GO:0000723],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
DNA recombination [GO:0006310],
regulation of telomere maintenance [GO:0032204],
negative regulation of telomere maintenance via telomerase [GO:0032211],
DNA duplex unwinding [GO:0032508],
negative regulation of telomerase activity [GO:0051974],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
magnesium ion binding [GO:0000287],
ATP binding [GO:0005524],
telomerase inhibitor activity [GO:0010521],
single-stranded DNA-dependent ATP-dependent DNA helicase activity [GO:0017116],
5'-3' DNA/RNA helicase activity [GO:0033678],
telomeric DNA binding [GO:0042162],
5'-3' DNA helicase activity [GO:0043139],
G-quadruplex DNA binding [GO:0051880],
nucleotide binding [GO:0000166],
DNA binding [GO:0003677],
DNA helicase activity [GO:0003678],
helicase activity [GO:0004386],
protein binding [GO:0005515],
hydrolase activity [GO:0016787],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
replication fork [GO:0005657],
mitochondrion [GO:0005739],
nucleus [GO:0005634],