PICALM

phosphatidylinositol binding clathrin assembly protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
endocytosis [GO:0006897],
receptor-mediated endocytosis [GO:0006898],
membrane budding [GO:0006900],
axonogenesis [GO:0007409],
learning or memory [GO:0007611],
negative regulation of gene expression [GO:0010629],
synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185],
synaptic vesicle maturation [GO:0016188],
vesicle-mediated transport [GO:0016192],
endosomal transport [GO:0016197],
hemopoiesis [GO:0030097],
regulation of endocytosis [GO:0030100],
receptor internalization [GO:0031623],
regulation of protein localization [GO:0032880],
cargo loading into vesicle [GO:0035459],
positive regulation of GTPase activity [GO:0043547],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of receptor-mediated endocytosis [GO:0048261],
clathrin coat assembly [GO:0048268],
synaptic vesicle endocytosis [GO:0048488],
dendrite morphogenesis [GO:0048813],
iron ion homeostasis [GO:0055072],
membrane organization [GO:0061024],
macromolecular complex assembly [GO:0065003],
clathrin-dependent endocytosis [GO:0072583],
modulation of age-related behavioral decline [GO:0090647],
regulation of vesicle size [GO:0097494],
positive regulation of neuron death [GO:1901216],
regulation of beta-amyloid formation [GO:1902003],
positive regulation of beta-amyloid formation [GO:1902004],
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959],
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961],
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963],
negative regulation of protein localization to plasma membrane [GO:1903077],
clathrin-coated pit assembly [GO:1905224],
negative regulation of protein localization to cell surface [GO:2000009],
multicellular organism development [GO:0007275],
positive regulation of axonogenesis [GO:0050772],
regulation of protein transport [GO:0051223],
regulation of synaptic vesicle endocytosis [GO:1900242],
positive regulation of synaptic vesicle endocytosis [GO:1900244],
regulation of synaptic vesicle transport [GO:1902803],
positive regulation of dendrite extension [GO:1903861],
regulation of terminal button organization [GO:2000331],
positive regulation of synaptic vesicle clustering [GO:2000809],

Molecular Function:
SNARE binding [GO:0000149],
beta-amyloid binding [GO:0001540],
protein binding [GO:0005515],
1-phosphatidylinositol binding [GO:0005545],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
Rab GTPase binding [GO:0017137],
clathrin binding [GO:0030276],
clathrin heavy chain binding [GO:0032050],
cadherin binding [GO:0045296],
tau protein binding [GO:0048156],
low-density lipoprotein particle receptor binding [GO:0050750],
phospholipid binding [GO:0005543],
SH3 domain binding [GO:0017124],
identical protein binding [GO:0042802],

Cellular Component:
nucleus [GO:0005634],
early endosome [GO:0005769],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
clathrin-coated pit [GO:0005905],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
membrane [GO:0016020],
AP-2 adaptor complex [GO:0030122],
clathrin coat of coated pit [GO:0030132],
clathrin-coated vesicle [GO:0030136],
intrinsic component of membrane [GO:0031224],
vesicle [GO:0031982],
presynaptic membrane [GO:0042734],
neuronal cell body [GO:0043025],
intracellular membrane-bounded organelle [GO:0043231],
postsynaptic membrane [GO:0045211],
clathrin-coated endocytic vesicle [GO:0045334],
perinuclear region of cytoplasm [GO:0048471],
endosome to plasma membrane transport vesicle [GO:0070381],
neurofibrillary tangle [GO:0097418],
extrinsic component of presynaptic endocytic zone [GO:0098894],
endosome [GO:0005768],
postsynaptic density [GO:0014069],
cytoplasmic vesicle [GO:0031410],
neuron projection [GO:0043005],
synapse [GO:0045202],
postsynapse [GO:0098794],