ATP6AP1

ATPase H+ transporting accessory protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
cellular iron ion homeostasis [GO:0006879],
insulin receptor signaling pathway [GO:0008286],
regulation of cellular pH [GO:0030641],
transferrin transport [GO:0033572],
ion transmembrane transport [GO:0034220],
cellular response to increased oxygen levels [GO:0036295],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of bone resorption [GO:0045780],
pH reduction [GO:0045851],
positive regulation of exocytosis [GO:0045921],
establishment of organelle localization [GO:0051656],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
hydrogen ion transmembrane transport [GO:1902600],
positive regulation of osteoclast development [GO:2001206],
ion transport [GO:0006811],
cell death [GO:0008219],
proton-transporting V-type ATPase complex assembly [GO:0070070],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
Rab GTPase binding [GO:0017137],
proton-transporting ATP synthase activity, rotational mechanism [GO:0046933],
proton-transporting ATPase activity, rotational mechanism [GO:0046961],
nucleotide binding [GO:0000166],

Cellular Component:
endoplasmic reticulum membrane [GO:0005789],
endosome membrane [GO:0010008],
integral component of membrane [GO:0016021],
proton-transporting two-sector ATPase complex [GO:0016469],
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116],
proton-transporting V-type ATPase, V1 domain [GO:0033180],
plasma membrane proton-transporting V-type ATPase complex [GO:0033181],
extracellular exosome [GO:0070062],
endoplasmic reticulum [GO:0005783],
membrane [GO:0016020],