PF4

platelet factor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31543366 Brain Mouse YES
31945054 IMR-90 Human YES
31964978 Primary astrocytes derived from brain Mouse YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31543366 WA09 Human YES

GO terms:

Biological Process:
platelet degranulation [GO:0002576],
inflammatory response [GO:0006954],
immune response [GO:0006955],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
positive regulation of gene expression [GO:0010628],
positive regulation of macrophage derived foam cell differentiation [GO:0010744],
negative regulation of angiogenesis [GO:0016525],
cytokine-mediated signaling pathway [GO:0019221],
platelet activation [GO:0030168],
neutrophil chemotaxis [GO:0030593],
leukocyte chemotaxis [GO:0030595],
positive regulation of tumor necrosis factor production [GO:0032760],
regulation of cell proliferation [GO:0042127],
defense response to protozoan [GO:0042832],
negative regulation of MHC class II biosynthetic process [GO:0045347],
positive regulation of macrophage differentiation [GO:0045651],
regulation of megakaryocyte differentiation [GO:0045652],
negative regulation of megakaryocyte differentiation [GO:0045653],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
killing by host of symbiont cells [GO:0051873],
chemokine-mediated signaling pathway [GO:0070098],
cellular response to lipopolysaccharide [GO:0071222],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
chemotaxis [GO:0006935],
defense response [GO:0006952],
killing of cells of other organism [GO:0031640],
macromolecular complex assembly [GO:0065003],

Molecular Function:
protein binding [GO:0005515],
chemokine activity [GO:0008009],
heparin binding [GO:0008201],
CXCR chemokine receptor binding [GO:0045236],
CXCR3 chemokine receptor binding [GO:0048248],
cytokine activity [GO:0005125],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
symbiont-containing vacuole membrane [GO:0020005],
host cell cytoplasm [GO:0030430],
platelet alpha granule lumen [GO:0031093],
platelet alpha granule [GO:0031091],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],