PDXK

pyridoxal kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
pyridoxal 5'-phosphate salvage [GO:0009443],
phosphorylation [GO:0016310],
vitamin B6 metabolic process [GO:0042816],
neutrophil degranulation [GO:0043312],
pyridoxal phosphate biosynthetic process [GO:0042823],
negative regulation of apoptotic process [GO:0043066],

Molecular Function:
magnesium ion binding [GO:0000287],
ATP binding [GO:0005524],
zinc ion binding [GO:0008270],
pyridoxal kinase activity [GO:0008478],
pyridoxal phosphate binding [GO:0030170],
potassium ion binding [GO:0030955],
sodium ion binding [GO:0031402],
lithium ion binding [GO:0031403],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
drug binding [GO:0008144],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],
pyridoxal binding [GO:0070280],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
secretory granule lumen [GO:0034774],
specific granule lumen [GO:0035580],
extracellular exosome [GO:0070062],
cytoplasm [GO:0005737],