PDPN

podoplanin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES

GO terms:

Biological Process:
cell morphogenesis [GO:0000902],
lymphangiogenesis [GO:0001946],
amino acid transmembrane transport [GO:0003333],
water transport [GO:0006833],
amino acid transport [GO:0006865],
Rho protein signal transduction [GO:0007266],
negative regulation of cell proliferation [GO:0008285],
regulation of cell shape [GO:0008360],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
folic acid transport [GO:0015884],
platelet activation [GO:0030168],
lung development [GO:0030324],
positive regulation of cell migration [GO:0030335],
tube morphogenesis [GO:0035239],
negative regulation of apoptotic process [GO:0043066],
wound healing, spreading of cells [GO:0044319],
lymph node development [GO:0048535],
positive regulation of cellular component movement [GO:0051272],
response to hyperoxia [GO:0055093],
lymphatic endothelial cell fate commitment [GO:0060838],
actin-mediated cell contraction [GO:0070252],
positive regulation of extracellular matrix disassembly [GO:0090091],
cell-cell adhesion [GO:0098609],
regulation of substrate adhesion-dependent cell spreading [GO:1900024],
positive regulation of platelet aggregation [GO:1901731],
regulation of myofibroblast contraction [GO:1904328],
regulation of lamellipodium morphogenesis [GO:2000392],
prostaglandin metabolic process [GO:0006693],
movement of cell or subcellular component [GO:0006928],
cell adhesion [GO:0007155],
signal transduction [GO:0007165],
multicellular organism development [GO:0007275],
cell proliferation [GO:0008283],
positive regulation of platelet activation [GO:0010572],
regulation of cell adhesion [GO:0030155],
lung alveolus development [GO:0048286],
visceral serous pericardium development [GO:0061032],
regulation of G1/S transition of mitotic cell cycle [GO:2000045],

Molecular Function:
receptor binding [GO:0005102],
water transmembrane transporter activity [GO:0005372],
protein binding [GO:0005515],
folic acid transporter activity [GO:0008517],
amino acid transmembrane transporter activity [GO:0015171],
water channel activity [GO:0015250],
chemokine binding [GO:0019956],
chaperone binding [GO:0051087],

Cellular Component:
ruffle [GO:0001726],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
lamellipodium [GO:0030027],
cell junction [GO:0030054],
filopodium [GO:0030175],
lamellipodium membrane [GO:0031258],
cytoplasmic vesicle [GO:0031410],
filopodium membrane [GO:0031527],
microvillus membrane [GO:0031528],
ruffle membrane [GO:0032587],
cell projection [GO:0042995],
membrane raft [GO:0045121],
invadopodium [GO:0071437],
tetraspanin-enriched microdomain [GO:0097197],
external side of plasma membrane [GO:0009897],
integral component of membrane [GO:0016021],