pyruvate dehydrogenase kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
glucose metabolic process [GO:0006006],
regulation of gluconeogenesis [GO:0006111],
protein phosphorylation [GO:0006468],
regulation of pH [GO:0006885],
insulin receptor signaling pathway [GO:0008286],
regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510],
regulation of cellular ketone metabolic process [GO:0010565],
regulation of glucose metabolic process [GO:0010906],
cellular response to nutrient [GO:0031670],
cellular response to reactive oxygen species [GO:0034614],
glucose homeostasis [GO:0042593],
regulation of calcium-mediated signaling [GO:0050848],
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332],
negative regulation of pyruvate dehydrogenase activity [GO:1904183],
carbohydrate metabolic process [GO:0005975],
phosphorylation [GO:0016310],
peptidyl-serine phosphorylation [GO:0018105],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740],
ATP binding [GO:0005524],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
cytosol [GO:0005829],
mitochondrial pyruvate dehydrogenase complex [GO:0005967],
pyruvate dehydrogenase complex [GO:0045254],