ATPase plasma membrane Ca2+ transporting 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23466301 Primary mesenchymal stem cells from bone marrow Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
neural retina development [GO:0003407],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
cellular calcium ion homeostasis [GO:0006874],
spermatogenesis [GO:0007283],
negative regulation of gene expression [GO:0010629],
negative regulation of nitric oxide mediated signal transduction [GO:0010751],
urinary bladder smooth muscle contraction [GO:0014832],
negative regulation of angiogenesis [GO:0016525],
hippocampus development [GO:0021766],
flagellated sperm motility [GO:0030317],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
ion transmembrane transport [GO:0034220],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
negative regulation of nitric oxide biosynthetic process [GO:0045019],
negative regulation of nitric-oxide synthase activity [GO:0051001],
regulation of cytosolic calcium ion concentration [GO:0051480],
response to hydrostatic pressure [GO:0051599],
calcium ion transmembrane transport [GO:0070588],
negative regulation of calcineurin-NFAT signaling cascade [GO:0070885],
cellular response to epinephrine stimulus [GO:0071872],
calcium ion transmembrane import into cytosol [GO:0097553],
calcium ion import across plasma membrane [GO:0098703],
negative regulation of the force of heart contraction [GO:0098736],
negative regulation of arginine catabolic process [GO:1900082],
calcium ion export [GO:1901660],
negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083],
regulation of sodium ion transmembrane transport [GO:1902305],
negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548],
regulation of cell cycle G1/S phase transition [GO:1902806],
positive regulation of protein localization to plasma membrane [GO:1903078],
negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243],
negative regulation of citrulline biosynthetic process [GO:1903249],
regulation of cardiac conduction [GO:1903779],
cellular response to acetylcholine [GO:1905145],
positive regulation of cAMP-dependent protein kinase activity [GO:2000481],
ion transport [GO:0006811],
calcium ion transport [GO:0006816],

Molecular Function:
calcium-transporting ATPase activity [GO:0005388],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
calcium ion transmembrane transporter activity [GO:0015085],
sodium channel regulator activity [GO:0017080],
cation-transporting ATPase activity [GO:0019829],
protein kinase binding [GO:0019901],
PDZ domain binding [GO:0030165],
protein phosphatase 2B binding [GO:0030346],
nitric-oxide synthase inhibitor activity [GO:0036487],
metal ion binding [GO:0046872],
calcium-dependent protein binding [GO:0048306],
nitric-oxide synthase binding [GO:0050998],
scaffold protein binding [GO:0097110],
nucleotide binding [GO:0000166],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
caveola [GO:0005901],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
Z disc [GO:0030018],
T-tubule [GO:0030315],
macromolecular complex [GO:0032991],
sperm flagellum [GO:0036126],
neuron projection [GO:0043005],
intracellular membrane-bounded organelle [GO:0043231],
membrane raft [GO:0045121],
sperm principal piece [GO:0097228],
glutamatergic synapse [GO:0098978],
integral component of presynaptic active zone membrane [GO:0099059],
cilium [GO:0005929],
integral component of membrane [GO:0016021],
motile cilium [GO:0031514],
sarcolemma [GO:0042383],
cell projection [GO:0042995],