PDGFRB

platelet derived growth factor receptor beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31584878 A-10 Rat NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
in utero embryonic development [GO:0001701],
tissue homeostasis [GO:0001894],
glycosaminoglycan biosynthetic process [GO:0006024],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
G-protein coupled receptor signaling pathway [GO:0007186],
multicellular organism development [GO:0007275],
aging [GO:0007568],
positive regulation of cell proliferation [GO:0008284],
male gonad development [GO:0008584],
positive regulation of phospholipase C activity [GO:0010863],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
positive regulation of smooth muscle cell migration [GO:0014911],
cell migration [GO:0016477],
peptidyl-tyrosine phosphorylation [GO:0018108],
adrenal gland development [GO:0030325],
positive regulation of cell migration [GO:0030335],
response to estradiol [GO:0032355],
positive regulation of phosphoprotein phosphatase activity [GO:0032516],
response to retinoic acid [GO:0032526],
regulation of actin cytoskeleton organization [GO:0032956],
positive regulation of collagen biosynthetic process [GO:0032967],
positive regulation of kinase activity [GO:0033674],
response to fluid shear stress [GO:0034405],
positive regulation of Rho protein signal transduction [GO:0035025],
cell migration involved in vasculogenesis [GO:0035441],
metanephric mesenchymal cell migration [GO:0035789],
platelet-derived growth factor receptor-beta signaling pathway [GO:0035791],
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793],
aorta morphogenesis [GO:0035909],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091],
wound healing [GO:0042060],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
response to estrogen [GO:0043627],
positive regulation of mitotic nuclear division [GO:0045840],
phosphatidylinositol metabolic process [GO:0046488],
protein autophosphorylation [GO:0046777],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
phosphatidylinositol-mediated signaling [GO:0048015],
positive regulation of fibroblast proliferation [GO:0048146],
embryonic organ development [GO:0048568],
positive regulation of smooth muscle cell proliferation [GO:0048661],
skeletal system morphogenesis [GO:0048705],
smooth muscle tissue development [GO:0048745],
inner ear development [GO:0048839],
regulation of peptidyl-tyrosine phosphorylation [GO:0050730],
positive regulation of chemotaxis [GO:0050921],
positive regulation of protein kinase B signaling [GO:0051897],
cardiac myofibril assembly [GO:0055003],
response to hyperoxia [GO:0055093],
cell chemotaxis [GO:0060326],
lung growth [GO:0060437],
cell migration involved in coronary angiogenesis [GO:0060981],
retina vasculature development in camera-type eye [GO:0061298],
cellular response to hydrogen peroxide [GO:0070301],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
smooth muscle cell chemotaxis [GO:0071670],
metanephric mesenchyme development [GO:0072075],
metanephric glomerular mesangial cell proliferation involved in metanephros development [GO:0072262],
metanephric glomerular capillary formation [GO:0072277],
metanephric comma-shaped body morphogenesis [GO:0072278],
metanephric S-shaped body morphogenesis [GO:0072284],
positive regulation of calcium ion import [GO:0090280],
ruffle assembly [GO:0097178],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
positive regulation of hepatic stellate cell activation [GO:2000491],
positive regulation of DNA biosynthetic process [GO:2000573],
blood vessel development [GO:0001568],
kidney development [GO:0001822],
protein phosphorylation [GO:0006468],
nitrogen compound metabolic process [GO:0006807],
chemotaxis [GO:0006935],
phosphorylation [GO:0016310],
hemopoiesis [GO:0030097],
intracellular signal transduction [GO:0035556],
cardiac vascular smooth muscle cell differentiation [GO:0060947],
metanephric glomerular mesangium development [GO:0072223],

Molecular Function:
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
platelet activating factor receptor activity [GO:0004992],
platelet-derived growth factor-activated receptor activity [GO:0005017],
platelet-derived growth factor beta-receptor activity [GO:0005019],
receptor binding [GO:0005102],
platelet-derived growth factor receptor binding [GO:0005161],
protein binding [GO:0005515],
ATP binding [GO:0005524],
growth factor binding [GO:0019838],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
vascular endothelial growth factor binding [GO:0038085],
phosphatidylinositol 3-kinase binding [GO:0043548],
platelet-derived growth factor binding [GO:0048407],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
ruffle [GO:0001726],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
focal adhesion [GO:0005925],
cell surface [GO:0009986],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
intrinsic component of plasma membrane [GO:0031226],
cytoplasmic vesicle [GO:0031410],
lysosomal lumen [GO:0043202],
intracellular membrane-bounded organelle [GO:0043231],
receptor complex [GO:0043235],
lysosome [GO:0005764],
integral component of membrane [GO:0016021],