PDGFRA

platelet derived growth factor receptor alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31129096 Muscle Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
luteinization [GO:0001553],
in utero embryonic development [GO:0001701],
cell activation [GO:0001775],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
multicellular organism development [GO:0007275],
estrogen metabolic process [GO:0008210],
positive regulation of cell proliferation [GO:0008284],
negative regulation of platelet activation [GO:0010544],
positive regulation of phospholipase C activity [GO:0010863],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
viral process [GO:0016032],
peptidyl-tyrosine phosphorylation [GO:0018108],
signal transduction involved in regulation of gene expression [GO:0023019],
extracellular matrix organization [GO:0030198],
lung development [GO:0030324],
adrenal gland development [GO:0030325],
positive regulation of cell migration [GO:0030335],
male genitalia development [GO:0030539],
Leydig cell differentiation [GO:0033327],
positive regulation of kinase activity [GO:0033674],
cellular response to reactive oxygen species [GO:0034614],
platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790],
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091],
wound healing [GO:0042060],
odontogenesis of dentin-containing tooth [GO:0042475],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
protein autophosphorylation [GO:0046777],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
phosphatidylinositol-mediated signaling [GO:0048015],
positive regulation of fibroblast proliferation [GO:0048146],
embryonic digestive tract morphogenesis [GO:0048557],
embryonic cranial skeleton morphogenesis [GO:0048701],
embryonic skeletal system morphogenesis [GO:0048704],
regulation of chemotaxis [GO:0050920],
positive regulation of protein kinase B signaling [GO:0051897],
cardiac myofibril assembly [GO:0055003],
palate development [GO:0060021],
face morphogenesis [GO:0060325],
cell chemotaxis [GO:0060326],
retina vasculature development in camera-type eye [GO:0061298],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
platelet aggregation [GO:0070527],
cellular response to amino acid stimulus [GO:0071230],
metanephric glomerular capillary formation [GO:0072277],
regulation of actin cytoskeleton reorganization [GO:2000249],
regulation of mesenchymal stem cell differentiation [GO:2000739],
hematopoietic progenitor cell differentiation [GO:0002244],
protein phosphorylation [GO:0006468],
chemotaxis [GO:0006935],
female gonad development [GO:0008585],
anatomical structure morphogenesis [GO:0009653],
animal organ morphogenesis [GO:0009887],
phosphorylation [GO:0016310],
cell migration [GO:0016477],
skeletal system morphogenesis [GO:0048705],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
lung growth [GO:0060437],
positive regulation of branching involved in lung morphogenesis [GO:0061047],

Molecular Function:
protein kinase activity [GO:0004672],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
platelet-derived growth factor alpha-receptor activity [GO:0005018],
vascular endothelial growth factor-activated receptor activity [GO:0005021],
platelet-derived growth factor receptor binding [GO:0005161],
protein binding [GO:0005515],
ATP binding [GO:0005524],
growth factor binding [GO:0019838],
vascular endothelial growth factor binding [GO:0038085],
protein homodimerization activity [GO:0042803],
macromolecular complex binding [GO:0044877],
platelet-derived growth factor binding [GO:0048407],
nucleotide binding [GO:0000166],
protein tyrosine kinase activity [GO:0004713],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
phosphatidylinositol 3-kinase binding [GO:0043548],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
microvillus [GO:0005902],
cilium [GO:0005929],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],
cell junction [GO:0030054],
intrinsic component of plasma membrane [GO:0031226],
macromolecular complex [GO:0032991],
receptor complex [GO:0043235],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
axon [GO:0030424],
cell projection [GO:0042995],