PDGFB

platelet derived growth factor subunit B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23934686 GP293 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
19219070 Ntv-a, Gtv-a, U-178MG, U-251MG, U-343MG, U-343MGa, U-1242MG, 164SK, AG1523 Human, mouse NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
embryonic placenta development [GO:0001892],
positive regulation of endothelial cell proliferation [GO:0001938],
monocyte chemotaxis [GO:0002548],
platelet degranulation [GO:0002576],
positive regulation of glomerular filtration [GO:0003104],
protein phosphorylation [GO:0006468],
heart development [GO:0007507],
positive regulation of cell proliferation [GO:0008284],
response to wounding [GO:0009611],
negative regulation of phosphatidylinositol biosynthetic process [GO:0010512],
negative regulation of platelet activation [GO:0010544],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
positive regulation of smooth muscle cell migration [GO:0014911],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-tyrosine phosphorylation [GO:0018108],
hemopoiesis [GO:0030097],
extracellular matrix organization [GO:0030198],
positive regulation of cell migration [GO:0030335],
positive regulation of protein autophosphorylation [GO:0031954],
negative regulation of protein binding [GO:0032091],
activation of protein kinase activity [GO:0032147],
activation of protein kinase B activity [GO:0032148],
interleukin-18-mediated signaling pathway [GO:0035655],
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793],
paracrine signaling [GO:0038001],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737],
positive regulation of mitotic nuclear division [GO:0045840],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
positive regulation of fibroblast proliferation [GO:0048146],
positive regulation of smooth muscle cell proliferation [GO:0048661],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
positive chemotaxis [GO:0050918],
positive regulation of chemotaxis [GO:0050921],
positive regulation of cell division [GO:0051781],
positive regulation of protein kinase B signaling [GO:0051897],
cell chemotaxis [GO:0060326],
positive regulation of protein tyrosine kinase activity [GO:0061098],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
protein kinase C signaling [GO:0070528],
cellular response to growth factor stimulus [GO:0071363],
cellular response to mycophenolic acid [GO:0071506],
positive regulation of glomerular mesangial cell proliferation [GO:0072126],
metanephric glomerular mesangial cell development [GO:0072255],
reactive oxygen species metabolic process [GO:0072593],
positive regulation of calcium ion import [GO:0090280],
positive regulation of hyaluronan biosynthetic process [GO:1900127],
negative regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902894],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
negative regulation of vascular smooth muscle cell differentiation [GO:1905064],
positive regulation of vascular smooth muscle cell dedifferentiation [GO:1905176],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
positive regulation of DNA biosynthetic process [GO:2000573],
positive regulation of metanephric mesenchymal cell migration [GO:2000591],
blood vessel development [GO:0001568],
substrate-dependent cell migration [GO:0006929],
multicellular organism development [GO:0007275],
synapse assembly [GO:0007416],
neuron remodeling [GO:0016322],
glial cell development [GO:0021782],
cell projection assembly [GO:0030031],
actin cytoskeleton organization [GO:0030036],
negative regulation of cell migration [GO:0030336],
positive regulation of collagen biosynthetic process [GO:0032967],
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033],
eye photoreceptor cell development [GO:0042462],
positive regulation of DNA replication [GO:0045740],
positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743],
positive regulation of vasoconstriction [GO:0045907],
positive regulation of mitotic cell cycle, embryonic [GO:0045977],
blood vessel morphogenesis [GO:0048514],
regulation of peptidyl-tyrosine phosphorylation [GO:0050730],
retina development in camera-type eye [GO:0060041],
branching involved in salivary gland morphogenesis [GO:0060445],
epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664],
cardiac vascular smooth muscle cell differentiation [GO:0060947],
retina vasculature development in camera-type eye [GO:0061298],
metanephric glomerular mesangial cell proliferation involved in metanephros development [GO:0072262],
metanephric glomerular endothelium development [GO:0072264],
positive regulation of hepatic stellate cell proliferation [GO:1904899],
positive regulation of hepatic stellate cell activation [GO:2000491],

Molecular Function:
platelet-derived growth factor receptor binding [GO:0005161],
protein binding [GO:0005515],
collagen binding [GO:0005518],
growth factor activity [GO:0008083],
superoxide-generating NADPH oxidase activator activity [GO:0016176],
chemoattractant activity [GO:0042056],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
platelet-derived growth factor binding [GO:0048407],
growth factor receptor binding [GO:0070851],
receptor binding [GO:0005102],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
endoplasmic reticulum lumen [GO:0005788],
Golgi lumen [GO:0005796],
cell surface [GO:0009986],
basolateral plasma membrane [GO:0016323],
platelet alpha granule lumen [GO:0031093],
membrane [GO:0016020],
dendrite [GO:0030425],
neuronal cell body [GO:0043025],