PDE9A

phosphodiesterase 9A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30977188 MSC Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
signal transduction [GO:0007165],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
cGMP-mediated signaling [GO:0019934],
cGMP metabolic process [GO:0046068],
cGMP catabolic process [GO:0046069],

Molecular Function:
3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114],
protein binding [GO:0005515],
metal ion binding [GO:0046872],
3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555],
phosphoric diester hydrolase activity [GO:0008081],
hydrolase activity [GO:0016787],
identical protein binding [GO:0042802],

Cellular Component:
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
ruffle membrane [GO:0032587],
sarcolemma [GO:0042383],
perikaryon [GO:0043204],
perinuclear region of cytoplasm [GO:0048471],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
membrane [GO:0016020],
cell projection [GO:0042995],