phosphodiesterase 2A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
heart valve development [GO:0003170],
ventricular septum development [GO:0003281],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
positive regulation of gene expression [GO:0010628],
negative regulation of cGMP-mediated signaling [GO:0010754],
regulation of mitochondrion organization [GO:0010821],
cAMP-mediated signaling [GO:0019933],
cGMP-mediated signaling [GO:0019934],
cellular response to drug [GO:0035690],
aorta development [GO:0035904],
cellular response to macrophage colony-stimulating factor stimulus [GO:0036006],
negative regulation of vascular permeability [GO:0043116],
positive regulation of vascular permeability [GO:0043117],
negative regulation of cAMP-mediated signaling [GO:0043951],
cGMP catabolic process [GO:0046069],
positive regulation of inflammatory response [GO:0050729],
establishment of endothelial barrier [GO:0061028],
cellular response to mechanical stimulus [GO:0071260],
cellular response to cAMP [GO:0071320],
cellular response to cGMP [GO:0071321],
cellular response to transforming growth factor beta stimulus [GO:0071560],
cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613],
cardiac septum development [GO:0003279],
signal transduction [GO:0007165],
heart development [GO:0007507],
regulation of nitric oxide mediated signal transduction [GO:0010749],
negative regulation of cell death [GO:0060548],
coronary vasculature development [GO:0060976],
cellular response to lipopolysaccharide [GO:0071222],
negative regulation of oxidative phosphorylation [GO:0090324],
cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011],

Molecular Function:
magnesium ion binding [GO:0000287],
3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115],
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118],
protein binding [GO:0005515],
drug binding [GO:0008144],
zinc ion binding [GO:0008270],
cAMP binding [GO:0030552],
cGMP binding [GO:0030553],
TPR domain binding [GO:0030911],
phosphate ion binding [GO:0042301],
protein homodimerization activity [GO:0042803],
3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555],
nucleotide binding [GO:0000166],
3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114],
phosphoric diester hydrolase activity [GO:0008081],
hydrolase activity [GO:0016787],
GAF domain binding [GO:0036004],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrial outer membrane [GO:0005741],
mitochondrial inner membrane [GO:0005743],
mitochondrial matrix [GO:0005759],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
presynaptic membrane [GO:0042734],
perinuclear region of cytoplasm [GO:0048471],
mitochondrion [GO:0005739],
membrane [GO:0016020],
axon [GO:0030424],
dendrite [GO:0030425],
membrane raft [GO:0045121],
synaptic membrane [GO:0097060],
hippocampal mossy fiber [GO:0097457],