ATP2A3

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
30988157 IMR-90 Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
calcium ion transport [GO:0006816],
cellular calcium ion homeostasis [GO:0006874],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
ion transmembrane transport [GO:0034220],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
calcium ion transmembrane transport [GO:0070588],
negative regulation of receptor binding [GO:1900121],
hydrogen ion transmembrane transport [GO:1902600],
calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515],
regulation of cardiac conduction [GO:1903779],
ion transport [GO:0006811],
endoplasmic reticulum calcium ion homeostasis [GO:0032469],

Molecular Function:
calcium-transporting ATPase activity [GO:0005388],
ATP binding [GO:0005524],
hydrogen-exporting ATPase activity, phosphorylative mechanism [GO:0008553],
cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656],
calcium ion transmembrane transporter activity [GO:0015085],
ATPase activity [GO:0016887],
calcium-dependent ATPase activity [GO:0030899],
ion channel binding [GO:0044325],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],

Cellular Component:
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
integral component of membrane [GO:0016021],
sarcoplasmic reticulum [GO:0016529],
organelle membrane [GO:0031090],
platelet dense tubular network membrane [GO:0031095],
nuclear membrane [GO:0031965],
sarcoplasmic reticulum membrane [GO:0033017],
membrane [GO:0016020],