ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31915373 Hheart_LA_VS healthy nan Human NO
31915373 Hheart_LV_VS healthy nan Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
regulation of the force of heart contraction [GO:0002026],
skeletal muscle contraction [GO:0003009],
cellular calcium ion homeostasis [GO:0006874],
ER-nucleus signaling pathway [GO:0006984],
organelle organization [GO:0006996],
cell adhesion [GO:0007155],
epidermis development [GO:0008544],
positive regulation of heart rate [GO:0010460],
regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882],
transition between fast and slow fiber [GO:0014883],
cardiac muscle hypertrophy in response to stress [GO:0014898],
endoplasmic reticulum calcium ion homeostasis [GO:0032469],
positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470],
response to lipopolysaccharide [GO:0032496],
T-tubule organization [GO:0033292],
ion transmembrane transport [GO:0034220],
cellular response to oxidative stress [GO:0034599],
cellular response to heat [GO:0034605],
response to endoplasmic reticulum stress [GO:0034976],
negative regulation of heart contraction [GO:0045822],
relaxation of cardiac muscle [GO:0055119],
sarcoplasmic reticulum calcium ion transport [GO:0070296],
calcium ion transmembrane transport [GO:0070588],
regulation of cardiac muscle cell membrane potential [GO:0086036],
regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909],
negative regulation of receptor binding [GO:1900121],
hydrogen ion transmembrane transport [GO:1902600],
regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233],
calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515],
regulation of cardiac conduction [GO:1903779],
calcium ion import into sarcoplasmic reticulum [GO:1990036],
ion transport [GO:0006811],
calcium ion transport [GO:0006816],
regulation of muscle contraction [GO:0006937],
response to peptide hormone [GO:0043434],

Molecular Function:
calcium-transporting ATPase activity [GO:0005388],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
ATP binding [GO:0005524],
hydrogen-exporting ATPase activity, phosphorylative mechanism [GO:0008553],
ATPase activity [GO:0016887],
enzyme binding [GO:0019899],
lutropin-choriogonadotropic hormone receptor binding [GO:0031775],
ion channel binding [GO:0044325],
S100 protein binding [GO:0044548],
calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [GO:0086039],
nucleotide binding [GO:0000166],
protein C-terminus binding [GO:0008022],
metal ion binding [GO:0046872],

Cellular Component:
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
integral component of plasma membrane [GO:0005887],
vesicle membrane [GO:0012506],
membrane [GO:0016020],
sarcoplasmic reticulum [GO:0016529],
platelet dense tubular network membrane [GO:0031095],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
macromolecular complex [GO:0032991],
sarcoplasmic reticulum membrane [GO:0033017],
perinuclear region of cytoplasm [GO:0048471],
ribbon synapse [GO:0097470],
intercalated disc [GO:0014704],
longitudinal sarcoplasmic reticulum [GO:0014801],
integral component of membrane [GO:0016021],
calcium ion-transporting ATPase complex [GO:0090534],