ATP1A2

ATPase Na+/K+ transporting subunit alpha 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
neurotransmitter uptake [GO:0001504],
behavioral fear response [GO:0001662],
regulation of the force of heart contraction [GO:0002026],
regulation of respiratory gaseous exchange by neurological system process [GO:0002087],
potassium ion transport [GO:0006813],
sodium ion transport [GO:0006814],
cellular sodium ion homeostasis [GO:0006883],
regulation of muscle contraction [GO:0006937],
regulation of smooth muscle contraction [GO:0006940],
regulation of striated muscle contraction [GO:0006942],
regulation of blood pressure [GO:0008217],
adult locomotory behavior [GO:0008344],
visual learning [GO:0008542],
establishment or maintenance of transmembrane electrochemical gradient [GO:0010248],
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881],
response to auditory stimulus [GO:0010996],
dephosphorylation [GO:0016311],
regulation of vasoconstriction [GO:0019229],
amygdala development [GO:0021764],
olfactory cortex development [GO:0021989],
cellular potassium ion homeostasis [GO:0030007],
ion transmembrane transport [GO:0034220],
response to nicotine [GO:0035094],
locomotory exploration behavior [GO:0035641],
sodium ion transmembrane transport [GO:0035725],
sodium ion export from cell [GO:0036376],
locomotion [GO:0040011],
negative regulation of heart contraction [GO:0045822],
positive regulation of heart contraction [GO:0045823],
negative regulation of striated muscle contraction [GO:0045988],
ATP metabolic process [GO:0046034],
negative regulation of cytosolic calcium ion concentration [GO:0051481],
regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946],
regulation of synaptic transmission, glutamatergic [GO:0051966],
relaxation of cardiac muscle [GO:0055119],
cardiac muscle contraction [GO:0060048],
cellular response to mechanical stimulus [GO:0071260],
cellular response to steroid hormone stimulus [GO:0071383],
potassium ion transmembrane transport [GO:0071805],
regulation of cardiac muscle cell contraction [GO:0086004],
membrane repolarization [GO:0086009],
membrane depolarization during cardiac muscle cell action potential [GO:0086012],
cell communication by electrical coupling involved in cardiac conduction [GO:0086064],
cation transmembrane transport [GO:0098655],
hydrogen ion transmembrane transport [GO:1902600],
negative regulation of calcium ion transmembrane transport [GO:1903170],
negative regulation of calcium:sodium antiporter activity [GO:1903280],
response to glycoside [GO:1903416],
regulation of cardiac conduction [GO:1903779],
potassium ion import across plasma membrane [GO:1990573],
ion transport [GO:0006811],

Molecular Function:
sodium:potassium-exchanging ATPase activity [GO:0005391],
protein binding [GO:0005515],
ATP binding [GO:0005524],
drug binding [GO:0008144],
phosphatase activity [GO:0016791],
ATPase activity [GO:0016887],
cation-transporting ATPase activity [GO:0019829],
potassium ion binding [GO:0030955],
sodium ion binding [GO:0031402],
protein heterodimerization activity [GO:0046982],
chaperone binding [GO:0051087],
steroid hormone binding [GO:1990239],
nucleotide binding [GO:0000166],
potassium-transporting ATPase activity [GO:0008556],
metal ion binding [GO:0046872],

Cellular Component:
cytoplasm [GO:0005737],
endosome [GO:0005768],
plasma membrane [GO:0005886],
sodium:potassium-exchanging ATPase complex [GO:0005890],
caveola [GO:0005901],
intercalated disc [GO:0014704],
membrane [GO:0016020],
T-tubule [GO:0030315],
organelle membrane [GO:0031090],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
extracellular vesicle [GO:1903561],
integral component of membrane [GO:0016021],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
myelin sheath [GO:0043209],
synapse [GO:0045202],