ATPase Na+/K+ transporting subunit alpha 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31799499 IMR-90 Human NO
31945054 IMR-90 Human YES

GO terms:

Biological Process:
regulation of the force of heart contraction [GO:0002026],
regulation of sodium ion transport [GO:0002028],
cellular sodium ion homeostasis [GO:0006883],
regulation of blood pressure [GO:0008217],
establishment or maintenance of transmembrane electrochemical gradient [GO:0010248],
dephosphorylation [GO:0016311],
cellular potassium ion homeostasis [GO:0030007],
negative regulation of glucocorticoid biosynthetic process [GO:0031947],
ion transmembrane transport [GO:0034220],
sodium ion export from cell [GO:0036376],
response to drug [GO:0042493],
negative regulation of heart contraction [GO:0045822],
positive regulation of heart contraction [GO:0045823],
positive regulation of striated muscle contraction [GO:0045989],
relaxation of cardiac muscle [GO:0055119],
membrane hyperpolarization [GO:0060081],
cellular response to mechanical stimulus [GO:0071260],
cellular response to steroid hormone stimulus [GO:0071383],
cardiac muscle cell action potential involved in contraction [GO:0086002],
regulation of cardiac muscle cell contraction [GO:0086004],
membrane repolarization [GO:0086009],
membrane repolarization during cardiac muscle cell action potential [GO:0086013],
cell communication by electrical coupling involved in cardiac conduction [GO:0086064],
hydrogen ion transmembrane transport [GO:1902600],
response to glycoside [GO:1903416],
regulation of cardiac conduction [GO:1903779],
potassium ion import across plasma membrane [GO:1990573],
ion transport [GO:0006811],
potassium ion transport [GO:0006813],
sodium ion transport [GO:0006814],
transmembrane transport [GO:0055085],

Molecular Function:
sodium:potassium-exchanging ATPase activity [GO:0005391],
protein binding [GO:0005515],
ATP binding [GO:0005524],
phosphatase activity [GO:0016791],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
ankyrin binding [GO:0030506],
potassium ion binding [GO:0030955],
sodium ion binding [GO:0031402],
ADP binding [GO:0043531],
phosphatidylinositol 3-kinase binding [GO:0043548],
protein heterodimerization activity [GO:0046982],
chaperone binding [GO:0051087],
steroid hormone binding [GO:1990239],
nucleotide binding [GO:0000166],
potassium-transporting ATPase activity [GO:0008556],
metal ion binding [GO:0046872],

Cellular Component:
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
sodium:potassium-exchanging ATPase complex [GO:0005890],
caveola [GO:0005901],
postsynaptic density [GO:0014069],
intercalated disc [GO:0014704],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
lateral plasma membrane [GO:0016328],
T-tubule [GO:0030315],
organelle membrane [GO:0031090],
macromolecular complex [GO:0032991],
sperm flagellum [GO:0036126],
sarcolemma [GO:0042383],
melanosome [GO:0042470],
membrane raft [GO:0045121],
photoreceptor inner segment membrane [GO:0060342],
extracellular exosome [GO:0070062],
extracellular vesicle [GO:1903561],
myelin sheath [GO:0043209],