ATP13A2

ATPase cation transporting 13A2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA68 Skin, Lung Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
cellular calcium ion homeostasis [GO:0006874],
cellular iron ion homeostasis [GO:0006879],
cellular zinc ion homeostasis [GO:0006882],
autophagy [GO:0006914],
lysosomal transport [GO:0007041],
positive regulation of gene expression [GO:0010628],
regulation of mitochondrion organization [GO:0010821],
regulation of macroautophagy [GO:0016241],
regulation of autophagosome size [GO:0016243],
cellular cation homeostasis [GO:0030003],
regulation of intracellular protein transport [GO:0033157],
ion transmembrane transport [GO:0034220],
cellular response to oxidative stress [GO:0034599],
protein autophosphorylation [GO:0046777],
positive regulation of protein secretion [GO:0050714],
regulation of endopeptidase activity [GO:0052548],
zinc ion homeostasis [GO:0055069],
lipid homeostasis [GO:0055088],
protein localization to lysosome [GO:0061462],
cellular response to manganese ion [GO:0071287],
cellular response to zinc ion [GO:0071294],
extracellular exosome biogenesis [GO:0097734],
regulation of protein localization to nucleus [GO:1900180],
negative regulation of neuron death [GO:1901215],
polyamine transmembrane transport [GO:1902047],
regulation of mitophagy [GO:1903146],
positive regulation of exosomal secretion [GO:1903543],
spermine transmembrane transport [GO:1903710],
regulation of chaperone-mediated autophagy [GO:1904714],
autophagosome organization [GO:1905037],
regulation of glucosylceramidase activity [GO:1905123],
regulation of lysosomal protein catabolic process [GO:1905165],
negative regulation of lysosomal protein catabolic process [GO:1905166],
peptidyl-aspartic acid autophosphorylation [GO:1990938],
regulation of ubiquitin-specific protease activity [GO:2000152],
cation transport [GO:0006812],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
zinc ion binding [GO:0008270],
ATPase activity [GO:0016887],
cation-transporting ATPase activity [GO:0019829],
manganese ion binding [GO:0030145],
phosphatidic acid binding [GO:0070300],
phosphatidylinositol-3,5-bisphosphate binding [GO:0080025],
cupric ion binding [GO:1903135],
nucleotide binding [GO:0000166],
metal ion binding [GO:0046872],

Cellular Component:
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
late endosome [GO:0005770],
multivesicular body [GO:0005771],
autophagosome [GO:0005776],
vesicle membrane [GO:0012506],
integral component of membrane [GO:0016021],
transport vesicle [GO:0030133],
vesicle [GO:0031982],
multivesicular body membrane [GO:0032585],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
lysosomal lumen [GO:0043202],
integral component of lysosomal membrane [GO:1905103],
membrane [GO:0016020],