PARP9

poly(ADP-ribose) polymerase family member 9

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
positive regulation of defense response to virus by host [GO:0002230],
immune system process [GO:0002376],
DNA repair [GO:0006281],
double-strand break repair [GO:0006302],
protein ADP-ribosylation [GO:0006471],
cellular response to DNA damage stimulus [GO:0006974],
posttranscriptional regulation of gene expression [GO:0010608],
negative regulation of gene expression [GO:0010629],
positive regulation of chromatin binding [GO:0035563],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
negative regulation of catalytic activity [GO:0043086],
innate immune response [GO:0045087],
positive regulation of transcription, DNA-templated [GO:0045893],
defense response to virus [GO:0051607],
regulation of response to interferon-gamma [GO:0060330],
positive regulation of interferon-gamma-mediated signaling pathway [GO:0060335],
protein poly-ADP-ribosylation [GO:0070212],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034],
cell migration [GO:0016477],
NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356],

Molecular Function:
transcription corepressor activity [GO:0003714],
NAD+ ADP-ribosyltransferase activity [GO:0003950],
enzyme inhibitor activity [GO:0004857],
transferase activity [GO:0016740],
enzyme binding [GO:0019899],
histone binding [GO:0042393],
ubiquitin-like protein ligase binding [GO:0044389],
ADP-D-ribose binding [GO:0072570],
STAT family protein binding [GO:0097677],
protein ADP-ribosylase activity [GO:1990404],
protein binding [GO:0005515],
NAD+ binding [GO:0070403],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
membrane [GO:0016020],