poly(ADP-ribose) polymerase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
DNA repair [GO:0006281],
base-excision repair [GO:0006284],
double-strand break repair [GO:0006302],
protein ADP-ribosylation [GO:0006471],
peptidyl-serine ADP-ribosylation [GO:0018312],
DNA ADP-ribosylation [GO:0030592],
positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051],
protein poly-ADP-ribosylation [GO:0070212],
extrinsic apoptotic signaling pathway [GO:0097191],
negative regulation of neuron death [GO:1901215],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
DNA binding [GO:0003677],
NAD+ ADP-ribosyltransferase activity [GO:0003950],
protein binding [GO:0005515],
protein ADP-ribosylase activity [GO:1990404],
transferase activity [GO:0016740],
transferase activity, transferring glycosyl groups [GO:0016757],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],