PARK7

Parkinsonism associated deglycase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
negative regulation of protein phosphorylation [GO:0001933],
positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866],
DNA repair [GO:0006281],
negative regulation of protein kinase activity [GO:0006469],
proteolysis [GO:0006508],
protein deglycosylation [GO:0006517],
autophagy [GO:0006914],
inflammatory response [GO:0006954],
mitochondrion organization [GO:0007005],
Ras protein signal transduction [GO:0007265],
single fertilization [GO:0007338],
adult locomotory behavior [GO:0008344],
methylglyoxal metabolic process [GO:0009438],
detoxification of copper ion [GO:0010273],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
histone modification [GO:0016570],
enzyme active site formation via L-cysteine sulfinic acid [GO:0018323],
lactate biosynthetic process [GO:0019249],
insulin secretion [GO:0030073],
positive regulation of protein complex assembly [GO:0031334],
negative regulation of protein ubiquitination [GO:0031397],
negative regulation of protein binding [GO:0032091],
activation of protein kinase B activity [GO:0032148],
negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
regulation of histone ubiquitination [GO:0033182],
negative regulation of protein sumoylation [GO:0033234],
positive regulation of NAD(P)H oxidase activity [GO:0033864],
cellular response to oxidative stress [GO:0034599],
regulation of histone acetylation [GO:0035065],
cellular response to glyoxal [GO:0036471],
peptidyl-cysteine deglycation [GO:0036526],
peptidyl-arginine deglycation [GO:0036527],
peptidyl-lysine deglycation [GO:0036528],
protein deglycation, glyoxal removal [GO:0036529],
protein deglycation, methylglyoxal removal [GO:0036530],
glutathione deglycation [GO:0036531],
glucose homeostasis [GO:0042593],
hydrogen peroxide metabolic process [GO:0042743],
negative regulation of apoptotic process [GO:0043066],
regulation of neuron apoptotic process [GO:0043523],
negative regulation of neuron apoptotic process [GO:0043524],
regulation of TRAIL receptor biosynthetic process [GO:0045560],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
glycolate biosynthetic process [GO:0046295],
negative regulation of protein export from nucleus [GO:0046826],
regulation of inflammatory response [GO:0050727],
detoxification of mercury ion [GO:0050787],
protein stabilization [GO:0050821],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
negative regulation of ubiquitin-protein transferase activity [GO:0051444],
dopamine uptake involved in synaptic transmission [GO:0051583],
regulation of mitochondrial membrane potential [GO:0051881],
positive regulation of protein kinase B signaling [GO:0051897],
membrane depolarization [GO:0051899],
membrane hyperpolarization [GO:0060081],
negative regulation of cell death [GO:0060548],
regulation of androgen receptor signaling pathway [GO:0060765],
methylglyoxal catabolic process to lactate [GO:0061727],
cellular response to hydrogen peroxide [GO:0070301],
cellular oxidant detoxification [GO:0098869],
positive regulation of protein localization to nucleus [GO:1900182],
negative regulation of neuron death [GO:1901215],
positive regulation of superoxide dismutase activity [GO:1901671],
negative regulation of protein acetylation [GO:1901984],
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],
regulation of fibril organization [GO:1902903],
positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958],
negative regulation of death-inducing signaling complex assembly [GO:1903073],
negative regulation of protein K48-linked deubiquitination [GO:1903094],
negative regulation of TRAIL-activated apoptotic signaling pathway [GO:1903122],
positive regulation of pyrroline-5-carboxylate reductase activity [GO:1903168],
positive regulation of tyrosine 3-monooxygenase activity [GO:1903178],
positive regulation of dopamine biosynthetic process [GO:1903181],
glyoxal metabolic process [GO:1903189],
glyoxal catabolic process [GO:1903190],
positive regulation of L-dopa biosynthetic process [GO:1903197],
positive regulation of L-dopa decarboxylase activity [GO:1903200],
negative regulation of oxidative stress-induced cell death [GO:1903202],
negative regulation of hydrogen peroxide-induced cell death [GO:1903206],
negative regulation of hydrogen peroxide-induced neuron death [GO:1903208],
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377],
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384],
negative regulation of reactive oxygen species biosynthetic process [GO:1903427],
positive regulation of reactive oxygen species biosynthetic process [GO:1903428],
positive regulation of mitophagy [GO:1903599],
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259],
negative regulation of ubiquitin-specific protease activity [GO:2000157],
positive regulation of oxidative phosphorylation uncoupler activity [GO:2000277],
positive regulation of transcription regulatory region DNA binding [GO:2000679],
positive regulation of androgen receptor activity [GO:2000825],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268],
synaptic transmission, dopaminergic [GO:0001963],
cellular response to DNA damage stimulus [GO:0006974],
response to oxidative stress [GO:0006979],
cellular response to reactive oxygen species [GO:0034614],
negative regulation of protein catabolic process [GO:0042177],
response to hydrogen peroxide [GO:0042542],
negative regulation of oxidative stress-induced neuron death [GO:1903204],
negative regulation of NMDA glutamate receptor activity [GO:1904782],
positive regulation of fertilization [GO:1905516],

Molecular Function:
core promoter sequence-specific DNA binding [GO:0001046],
double-stranded DNA binding [GO:0003690],
single-stranded DNA binding [GO:0003697],
transcription coactivator activity [GO:0003713],
mRNA binding [GO:0003729],
receptor binding [GO:0005102],
copper ion binding [GO:0005507],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
peptidase activity [GO:0008233],
superoxide dismutase copper chaperone activity [GO:0016532],
oxidoreductase activity, acting on peroxide as acceptor [GO:0016684],
enzyme binding [GO:0019899],
kinase binding [GO:0019900],
cytokine binding [GO:0019955],
tyrosine 3-monooxygenase activator activity [GO:0036470],
L-dopa decarboxylase activator activity [GO:0036478],
protein deglycase activity [GO:0036524],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
small protein activating enzyme binding [GO:0044388],
ubiquitin-like protein conjugating enzyme binding [GO:0044390],
macromolecular complex binding [GO:0044877],
cadherin binding [GO:0045296],
mercury ion binding [GO:0045340],
androgen receptor binding [GO:0050681],
peroxiredoxin activity [GO:0051920],
repressing transcription factor binding [GO:0070491],
scaffold protein binding [GO:0097110],
cupric ion binding [GO:1903135],
cuprous ion binding [GO:1903136],
ubiquitin-specific protease binding [GO:1990381],
glyoxalase (glycolic acid-forming) activity [GO:1990422],
RNA binding [GO:0003723],
hydrolase activity [GO:0016787],

Cellular Component:
chromatin [GO:0000785],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial intermembrane space [GO:0005758],
mitochondrial matrix [GO:0005759],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
PML body [GO:0016605],
axon [GO:0030424],
cell body [GO:0044297],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
presynapse [GO:0098793],
membrane [GO:0016020],
neuron projection [GO:0043005],