PAPPA

pappalysin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES
32042076 Primary fibroblasts derived from skin Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
female pregnancy [GO:0007565],
response to follicle-stimulating hormone [GO:0032354],
cellular protein metabolic process [GO:0044267],
response to glucocorticoid [GO:0051384],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
endopeptidase activity [GO:0004175],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],