atrophin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
central nervous system development [GO:0007417],
neuron apoptotic process [GO:0051402],
spermatogenesis [GO:0007283],
determination of adult lifespan [GO:0008340],
male gonad development [GO:0008584],
toxin metabolic process [GO:0009404],
post-embryonic development [GO:0009791],
cell migration [GO:0016477],
maintenance of cell polarity [GO:0030011],
response to food [GO:0032094],
multicellular organism growth [GO:0035264],

Molecular Function:
RNA polymerase II transcription factor binding [GO:0001085],
DNA binding [GO:0003677],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
protein domain specific binding [GO:0019904],
transcription coactivator activity [GO:0003713],
JUN kinase binding [GO:0008432],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
nuclear matrix [GO:0016363],
cell junction [GO:0030054],
perinuclear region of cytoplasm [GO:0048471],
cell leading edge [GO:0031252],