OPA1 mitochondrial dynamin like GTPase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
17545159 HeLa, Chang Human NO
33299530 kidney Mouse No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28552492 Muscle Mouse NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
mitochondrial genome maintenance [GO:0000002],
mitochondrial fission [GO:0000266],
dynamin family protein polymerization involved in mitochondrial fission [GO:0003374],
apoptotic process [GO:0006915],
mitochondrion organization [GO:0007005],
inner mitochondrial membrane organization [GO:0007007],
visual perception [GO:0007601],
mitochondrial fusion [GO:0008053],
positive regulation of mitochondrial fusion [GO:0010636],
positive regulation of neuron maturation [GO:0014042],
response to muscle activity [GO:0014850],
axonal transport of mitochondrion [GO:0019896],
calcium ion transmembrane import into mitochondrion [GO:0036444],
negative regulation of apoptotic process [GO:0043066],
GTP metabolic process [GO:0046039],
positive regulation of insulin receptor signaling pathway [GO:0046628],
organelle fission [GO:0048285],
intracellular distribution of mitochondria [GO:0048312],
protein oligomerization [GO:0051259],
response to electrical stimulus [GO:0051602],
retina development in camera-type eye [GO:0060041],
positive regulation of dendritic spine morphogenesis [GO:0061003],
membrane fusion [GO:0061025],
mitochondrion morphogenesis [GO:0070584],
cellular response to glucose stimulus [GO:0071333],
cellular response to hypoxia [GO:0071456],
cochlea development [GO:0090102],
negative regulation of release of cytochrome c from mitochondria [GO:0090201],
cellular senescence [GO:0090398],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],
response to curcumin [GO:1904643],
cellular response to L-glutamate [GO:1905232],
neural tube closure [GO:0001843],
response to stimulus [GO:0050896],
positive regulation of dendrite development [GO:1900006],
positive regulation of cellular response to insulin stimulus [GO:1900078],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],

Molecular Function:
magnesium ion binding [GO:0000287],
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
microtubule binding [GO:0008017],
kinase binding [GO:0019900],
macromolecular complex binding [GO:0044877],
phosphatidic acid binding [GO:0070300],
cardiolipin binding [GO:1901612],
nucleotide binding [GO:0000166],
lipid binding [GO:0008289],
hydrolase activity [GO:0016787],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
mitochondrial inner membrane [GO:0005743],
mitochondrial intermembrane space [GO:0005758],
cytosol [GO:0005829],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
mitochondrial crista [GO:0030061],
dendrite [GO:0030425],
extrinsic component of mitochondrial inner membrane [GO:0031314],
mitochondrial membrane [GO:0031966],
axon cytoplasm [GO:1904115],