ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29366775 | HAECs | Aorta | Human, mouse | NO |
| 31945054 | IMR-90 | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
GO terms:
Biological Process:
brainstem development [GO:0003360],
nucleobase-containing compound metabolic process [GO:0006139],
'de novo' IMP biosynthetic process [GO:0006189],
nucleoside metabolic process [GO:0009116],
purine ribonucleoside monophosphate biosynthetic process [GO:0009168],
response to inorganic substance [GO:0010035],
cerebellum development [GO:0021549],
cerebral cortex development [GO:0021987],
animal organ regeneration [GO:0031100],
dihydrofolate metabolic process [GO:0046452],
tetrahydrofolate biosynthetic process [GO:0046654],
cellular response to interleukin-7 [GO:0098761],
purine nucleotide biosynthetic process [GO:0006164],
metabolic process [GO:0008152],
ribonucleotide metabolic process [GO:0009259],
Molecular Function:
IMP cyclohydrolase activity [GO:0003937],
phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643],
protein homodimerization activity [GO:0042803],
cadherin binding [GO:0045296],
catalytic activity [GO:0003824],
transferase activity [GO:0016740],
hydrolase activity [GO:0016787],
Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
extracellular exosome [GO:0070062],
mitochondrion [GO:0005739],